Study Shows Effectiveness of Reduced Coronavirus Vaccine Booster Dose
A recent study conducted by researchers from Australia’s Murdoch Children’s Research Institute (MCRI) and Mongolia’s National Center for Infectious Diseases has shown that a reduced booster dose of the coronavirus vaccine can still elicit an immune response similar to that of the primary dose in adults.
The study focused on individuals who had previously received AstraZeneca and China’s Sinopharm vaccines, and found that administering a booster dose of half the Pfizer COVID-19 vaccine resulted in a comparable immune response to those who had received the full primary dose. However, the effectiveness of a half-dose booster was insufficient in comparison to adults who had received the Russian Sputnik V vaccine.
The researchers emphasized the potential benefits of reducing the vaccination dose, particularly in terms of increasing the acceptability of vaccine boosters and reducing the overall cost of vaccination. This finding holds potential significance for the vaccination strategy in low-income countries.
Importance of Boosting Vaccine Efficacy
As the efficacy of the coronavirus vaccine wanes over time, it becomes crucial to maintain its effectiveness through regular booster shots. In Korea, vaccines developed for prevalent mutant viruses are administered on an annual basis to ensure ongoing protection.
The study involved the analysis of immune responses to different booster doses in 601 Mongolian adults. Of these individuals, 300 received the full primary dose, while 301 received only half the dose. Surprisingly, the results indicated that the immune response in those who received only half the dose was not inferior to that of those who received the full dose.
Reduced Dose, Reduced Adverse Reactions
In addition to the comparable immune response, individuals who received only half the basic dose also reported experiencing less local pain at the vaccination site. Furthermore, adverse reactions such as fever, vomiting, diarrhea, and headache were less common among those who received only half the dose. These findings suggest that a reduced booster dose may not only maintain efficacy but also lead to fewer adverse reactions.
The implications of this study extend beyond individual efficacy, offering potential benefits for global vaccination strategies, particularly in low-income countries where cost and acceptability can be significant barriers to achieving widespread vaccination coverage.
A study showed that the Corona vaccine booster shot is effective even if it is only half of the basic dose. The research team said, “It will be useful in the vaccination strategy of low-income countries.” The photo shows the reception of a coronavirus vaccine in Korea./Newsis
A study showed that even if a smaller booster dose of the coronavirus vaccine is given, an immune response similar to the primary dose occurs in adults.
A team of researchers from Australia’s Murdoch Children’s Research Institute (MCRI) and Mongolia’s National Center for Infectious Diseases found that people who had previously received AstraZeneca and China’s Sinopharm vaccines received a booster dose of half the Pfizer COVID-19 vaccine, leading to a response immune similar to those who received the basic dose. It was said to show. However, compared to adults who received the Russian Sputnik V vaccine, half the dose was not effective enough. The research team said, “Reducing the vaccination dose may increase the acceptability of a coronavirus vaccine booster and reduce the cost of vaccination.”
The immune effect of the coronavirus vaccine decreases as time passes after receiving the vaccine. For this reason, it is important to maintain the effectiveness of vaccines by receiving additional vaccinations regularly. In Korea, vaccines developed for common mutant viruses are administered once a year.
The research team analyzed the immune response according to the corona vaccine booster dose in 601 Mongolian adults. The basic dose of the vaccine was given to 300 people, and only half was given to 301 people. The results showed that the immune response of those who received only half the dose was not inferior to that of those who received the basic dose.
In addition, people who received only half the basic dose had less local pain from vaccination, and adverse reactions such as fever, vomiting, diarrhoea, and headache were also less common among those who received only half the dose . The research team said, “The results of this study will be useful in the strategy of strengthening the coronavirus vaccine in low-income countries.”
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