▲ Professors Jang Hyung-woo and Kim Jun-seong from the Department of Cardiovascular and Thoracic Surgery at Bundang Hospital of Seoul National University and Professor Ahn So-yeon’s team at the Medical Research Collaboration Center
[미디어이슈=박종완 기자] A team led by Professors Jang Hyung-woo and Kim Jun-seong from the Department of Cardiovascular and Thoracic Surgery at Bundang Hospital of Seoul National University and Professor Ahn So-yeon from the Collaborating Center for Medical Research presented the findings of research showing that administration of the COVID-19 vaccine before coronary artery bypass surgery does not affect surgical outcome.
Following the COVID-19 pandemic, quarantine authorities are actively recommending vaccination to prepare for a resurgence. However, since rare cases of cardiac complications such as blood clot formation or myocarditis and acute myocardial infarction have been reported after vaccination, there has been a tendency to hesitate to receive the vaccine, especially among patients with high-risk cardiovascular disease. In current medical settings, we receive inquiries from patients with high-risk cardiovascular disease about the safety of pre- and postoperative COVID-19 vaccination and the appropriate interval between vaccination and surgery, but evidence for clear answers is lacking.
Accordingly, the research team conducted a retrospective study to determine whether receiving the COVID-19 vaccine before performing coronary artery bypass grafting (CABG) affected surgical outcome. Coronary artery bypass surgery is a surgery that creates a bypass that provides blood flow to the heart by connecting a blood vessel that can replace the narrowed coronary artery.
This study used data from 481 adult patients whose vaccination status was confirmed among adult patients undergoing coronary artery bypass surgery at Seoul National University Bundang Hospital from 2020 to 2022 and classified them into a unvaccinated group and a fully vaccinated group. It was considered complete when the manufacturer’s recommended number of vaccinations was reached (1 to 2 times). In order to reduce errors in the subsequent investigation process, a 1:1 propensity score matching was performed on the two groups, and finally, 156 patient pairs were compared and analyzed.
The research team confirmed the one-year survival rate and complication rate depending on whether or not the patient had received the coronavirus vaccine before surgery and the patency of blood vessels through CT angiography a year later. Additionally, survival rates by vaccine type and the interval between vaccination and surgery were compared between cases within 30 days and cases greater than 30 days.
[사진.코로나 백신 접종(1회 또는 2회)를 완료한 환자와 전혀 백신 접종을 받지 않은 환자의 생존 곡선 비교]
As a result of their analysis, it was found that there was no significant difference in the one-year survival rate and complication rate between patients who were not vaccinated before surgery and those who were fully vaccinated. Furthermore, it was confirmed that vaccination did not affect the rate of vascular patency after one year, which demonstrates the effectiveness of the treatment. The survival rate according to the type of vaccine and the interval between the date of vaccination and surgery showed no significant differences between the two groups.
Professor Jang Hyeong-woo said: “The results of this study showed that even in patients with such high cardiovascular risk as to undergo coronary artery bypass surgery, receiving a vaccine before coronary artery bypass surgery does not affect I don’t hesitate even a year after the surgery.” “Patients with high cardiovascular risk, such as hypertension, diabetes, hyperlipidemia and renal failure, should also consult their doctor and receive the COVID-19 vaccine, if possible, to prevent serious complications due to coronavirus infection,” he said.
The study was published in the “Journal of the American Heart Association”. The title of the article is “Influence of preoperative COVID-19 vaccination on outcomes after coronary artery bypass grafting: a propensity score-matched analysis.”
#adverse #effects #receiving #COVID19 #vaccine #coronary #artery #bypass #surgery #Seoul #National #University #Bundang #Hospital #media #issue
