Journalist Cho Min-gyu
awe0906@mdtoday.co.kr | 2024-05-10 17:51:41
▲ Research findings have shown that people with two copies of the APOE4 gene have a higher risk of Alzheimer’s disease.
(Photo = DB)
[메디컬투데이=조민규 기자] Research has shown that people with two copies of the APOE4 gene have a higher risk of Alzheimer’s disease.
A study published in “Nature Medicine” found that people with two copies of the APOE4 gene actually develop Alzheimer’s disease and its symptoms appear even at an early age.
Alzheimer’s disease is one of the most common types of dementia and is known as a degenerative brain disease accompanied by cognitive decline. The cause of Alzheimer’s disease is still unclear and it is known that an accumulation of abnormal proteins is observed.
Experts emphasize the need to identify risk factors for Alzheimer’s disease and slow the progression of the disease through prevention and early diagnosis.
The researchers analyzed about 3,000 brains donated to the US National Alzheimer’s Coordinating Center and clinical data from about 10,000 people in three countries.
Researchers reported that about 95 percent of people with two copies of the APOE4 gene had high levels of an abnormal protein called beta-amyloid in their spinal fluid. Additionally, 75% reported a positive brain scan for amyloid.
The results of this study could have implications for Eisai’s recently approved Alzheimer’s treatment “Leqembi” and for Biogen’s new drug that removes amyloid protein accumulated in the brain.
However, experts stressed that the study has clear limitations as most people of European descent participated and that further follow-up research targeting people of African descent is needed.
[ⓒ 메디컬투데이. 무단전재-재배포 금지]
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