The Baan Phra Athit Panthep Puaphongphan community has witnessed significant advancements in human knowledge and healthcare over the past decades. Scientific and medical progress has led to the development of antibiotics, improved hygiene practices, and better disease treatment processes. Notably, advancements in the treatment of coronary artery disease and heart disease have contributed to longer and healthier lives for individuals.
Looking back at historical events, the year 1925 marked a turning point in the United States’ health system, with measures taken to procure clean water and establish proper wastewater disposal systems to combat epidemics. During this time, the life expectancy of Americans was 59 years. Thailand, on the other hand, experienced a shorter life expectancy of only 40.3 years in 1937.
Around 1955, there was a significant breakthrough in healthcare with the development of multiple vaccines, such as smallpox, diphtheria, and polio vaccines. This led to a decrease in epidemic outbreaks and subsequently increased life expectancies worldwide. By this time, the average life expectancy was 50.1 years globally, with Americans living up to 60.3 years and Thais up to 47.1 years.
In 1985, the threat of epidemics decreased globally, and efforts were focused on combating heart disease, particularly by reducing the risks associated with smoking. Advances in medication and treatment procedures for heart disease further improved life expectancies. During this time, the average life expectancy worldwide reached 62.2 years, with Americans living up to 69.2 years and Thais up to 67.6 years.
By the year 2015, there were significant advancements in medicines for various diseases and the development of modern diagnostic tools and surgical procedures. These advancements led to a reduction in cancer mortality rates and improvements in overall health. Thai people had a life expectancy of about 77.7 years, while global life expectancy increased to 71.8 years, and Americans lived up to 76.3 years.
In 2019, the year COVID-19 emerged, Thai people’s life expectancy reached approximately 79 years. Globally, life expectancy was 72.8 years, and Americans had a life expectancy of 76.7 years. Over the 64-year period from 1955 to 2019, Thai people lived nearly 32 years longer, while global life expectancy increased by 22.7 years, and Americans gained an additional 16.4 years.
These improvements in life expectancy can be attributed to the rapid development of Thailand’s public health system, advancement in medical treatments, the skills of doctors, and various legal measures and campaigns, such as reducing smoking rates.
Over the years, there has been ongoing progress in pharmaceutical research. For example, Rapamycin, an antibiotic used in animal studies, has shown potential for prolonging life in laboratory animals. It inhibits the mTOR gene, which is responsible for growth inhibition, and has been used to treat cancer and prevent organ rejection in transplant patients. Clinical research on Rapamycin in humans is expected to be completed by December 2023.
Another intriguing development is RED-GEMs, a regenerative DNA molecule discovered by a research team from Chulalongkorn University in collaboration with PTT Company and Innobic (Asia) Co., Ltd. Animal models have shown positive results, with improvements in strength, activity, and softer quality of newborn pigs. Human clinical trials for RED-GEMs are expected to begin around 2023, with potential production and release by 2024.
The evolving field of consumer information and medicine has prompted The Economist magazine to hypothesize that people may live up to 120 years. While the potential to reverse aging through medication exists, it may not be a universal solution for all elderly individuals. However, with Thailand’s population retiring at 60 years old, their extended life expectancy has led to a longer period of “good” lifespan.
Thai males can expect an average of 68 years of healthy life, with a life expectancy of 72.2 years. This means that after retiring at 60, they can enjoy eight years of unemployment in good health, followed by four years of declining health before passing away. Thai females, on the other hand, have an average of 74 years of healthy life and a life expectancy of 78.9 years, resulting in 14 years of unemployment after retirement in good health and five years in poor health.
In conclusion, the Baan Phra Athit Panthep Puaphongphan community has witnessed remarkable progress in healthcare and medical research over the years. These advancements have considerably extended life expectancies, and ongoing research holds the potential for even further improvements in the future.
At Baan Phra Athit
Panthep Puaphongphan
Over the past decades, humans have evolved in terms of knowledge. more scientific and medical led to antibiotics better hygiene and the inclusion of better disease treatment processes (Especially the evolution of treatment for coronary artery disease and heart disease) has led to people living longer and longer. And having a long life As well as having anti aging medicine There has even started to be some evolution in anti aging medicine.
Time magazine has compiled a look back at historical events. Going back about 98 years ago, the year 1925 (1925) was a turning point in the health of the United States. which includes the procurement process Clean water, waste water disposal In order to reduce the epidemic in the United States[1]
At that time, the life expectancy of an American was 59 years.[1] Regarding Thailand, a statistical survey was conducted in 1937 (1937) that Thai people have a life expectancy of only 40.3 years, which is considered a very short life expectancy for Thai people.[2]
Later, another 30 years later, around the year 1955 (BE 2498), humanity had to thank a period of evolution. “Multiple vaccines” including smallpox (smallpox) vaccine, diphtheria vaccine, polio vaccine, etc., are vaccines produced to reduce outbreaks of epidemics that spread easily. and has caused many deaths. including virus control It has made people live longer.[1]
At that time, life expectancy worldwide increased to 50.1 years, with Americans having a life expectancy of 60.3 years and Thais having a life expectancy of 47.1 years.[2]
Over the next 30 years, in 1985, the threat of epidemics decreased worldwide. Public health in the United States has launched a campaign on heart disease. Especially reducing the risk of heart disease from cigarettes. During that time, medication and treatment procedures for heart disease have developed more.[1]
At that time, life expectancy worldwide increased to 62.2 years, with Americans living 69.2 years and Thais living 67.6 years.[2]
Another 30 years later, in the year 2015 (2015), there was the development of medicines to treat many diseases. Including the development of analytical tools for the diagnosis or screening or prevention of disease that are more modern and faster. Advances in surgery Including the evolution of other treatments Leads to a reduction in the death rate in some types of cancer. This includes treating other illnesses as well.
At that time, the life expectancy of Thai people was about 77.7 years, worldwide, life expectancy had increased to 71.8 years, and the life expectancy of Americans was 76.3 years.[2]
In the year 2019 (2019), which is the year the disease COVID-19 started. At the end of the year before the global outbreak spread, it was found that the life expectancy of Thai people was about 79 years. People around the world had a life expectancy that had increased to 72.8 years, and the life expectancy of Americans was 76.7 years.[2]
In summary, in the 64 years between 1955-2019 (1955-2015), Thai people lived 31.9 years longer. People around the world lived 22.7 years longer, while Americans lived 16.4 years longer.
for Thailand In addition to the public health system that has developed rapidly in many dimensions. along with the ability of doctors in Thailand and the treatment of diseases in Thailand that are as advanced as international ones. also comes from many legal measures and campaigns to “reduce smoking in Thailand” has also continued to decrease.[3]
In the year 2019 (2019), the global death rate due to smoking was found to be 13.0 percent, with Americans having the highest death rate due to cigarettes. The proportion is 17.5 percent, while the proportion of Thai people who dying as a result of cigarettes has decreased continuously until 2019, the proportion is 11.8 percent.[3]
In the year 2000, adults who smoked in the world accounted for 34.2 percent. In the United States, smoking accounted for 33.8 percent. In Thailand, smoking accounted for 31.7 percent. But 20 years have passed in the year 2000. 2020, one of the world Adult smokers decreased to 23 percent. The United States smoked cigarettes to 23 percent, while Thailand smoked to 22.1 percent.[3]
Also, if we go back to 2015, Time magazine had an interesting headline on its cover: This child will live to be 142. It refers to a drug called Rapamycin, which has been used as an antibiotic in laboratory animals. They then found that there was a mechanism to inhibit the activity of the gene called mTOR, leading to growth inhibition.
Rappamycin It is an antibiotic that is prepared for use in the treatment of fungal infections. Later, it was found to have the effect of suppressing the immune system. So it was used to treat kidney transplant patients. To prevent the immune system from rejecting the transplanted tissue.
It was later discovered that this drug inhibited the growth of cancer. Therefore, it is used to treat cancer Subsequent research has produced more and more evidence. that rapamycin helps laboratory rats live longer
Rappamycin acts on its target. This is a protein inside the cell called mTOR (mammalian target of rapamycin) The drug rapamycin blocks the activity of a gene called mTOR, reducing the incidence of cancer, Alzheimer’s, Parkin’s San, myocardial disease Diabetes type 2, a bone disease that leads to blocked growth or division It is like a period of fasting.
Regarding the progress of rapamycin, It has started to enter the research process with humans compared to placebo since 2020 and it is expected that the research will be completed around December 2023.[4]
For Thai people’s innovations that the world is watching is red gemstone molecule Or the English name is RED-GEMs.[5]-[7]
Red stone molecules or RED-GEMs, an abbreviation for regenerative DNA by GEnomic Stability Molecules, are the result of further discoveries. The “upstream aging mechanism” is the youth-DNA gap area where DNA methylation occurs and is the source of the red gemstone molecule.[5]-[7]
By this research Research team from Chulalongkorn University Collaboration in research with PTT Company. Co., Ltd. and Innobic (Asia) Co., Ltd.[5]
The progress made in animal models of the red gemstone molecule has been interesting: old diabetic rats became stronger and more active; the quality of newborn pigs weighing 100 kilograms became softer. Mice with Alzheimer’s, Parkinson’s disease, and pulmonary fibrosis: Research results not yet determined.[5]-[7]
By “Compared to the age of humans It will be like reducing old cells from 70 years old to 25 years old.” [5]
The next step will be to prepare for clinical testing of red gems in humans. Studies are expected to begin in 2023, with the rest depending on the results of human trials. Safety of red gemstone injections in humans It is hoped that it will be produced and released as early as 2024.[5]
The Economist magazine, issue September 30-October 6, 2023, once again featured on the cover the trend of people living up to 120 years due to the evolution of consumer information and the evolution of medicine Going back to a more advanced age[8]
The important question that follows is: How many people will have to get a lot of money? And there is plenty of potential to buy medicine that can reverse ageing.
But although there may not be a cure to reverse aging for all elderly citizens, But the Thai population, who retire at the age of 60, have a longer life expectancy. This has caused the average lifespan of being “good” to be further extended as well.
Thai males have an average of about 68 years of good health, with an average life expectancy of about 72.2 years. This means that when an elderly Thai male retires at age 60, he or she will be unemployed for up to 12 years, divided into being unemployed after a healthy retirement 8 years before his health deteriorated, another 4 years before his death.
Although Thai women have an average of about 74 years of good health, the average life expectancy is about 78.9 years, This means that when an elderly Thai woman retires at age 60, she will be unemployed for up to 18 years, having ‘to share being unemployed after retirement He was in good health for 14 years before being in poor health for another 5 years before he died.[9]
The question is, is it really appropriate for a Thai man who has been unemployed after 12 years of retirement despite 8 years of good health or a Thai woman who has been unemployed after 18 years of retirement despite being in good health for 14 years?
Maybe we need to start thinking about planning to care for the elderly more than just preparing a debt budget to provide welfare for the elderly only?
From the facts in 2021, it was found that about 1 in 3 elderly people aged 60 and above are still working, with more than 78.3 percent of elderly people with an income of less than 100,000 baht per year and 1 in 3 of elderly people are. People with low incomes below the poverty line In addition, people with savings of less than 50,000 baht and people of working age are burdened with increasing expenses for caring for the elderly. [9]
So, Thai elderly Should I not be unemployed and be employed for longer?
Should Thai seniors have a longer and more excellent period of health? Especially problems from alcohol, cigarettes and sugar, lack of exercise. Should it be a national agenda?
Should elderly Thais rely more on themselves in their families? Should have knowledge of using home herbs. Organic food in the family And there should be indicators and incentives that rely less on hospitals. Less dependence on foreign medicine or not?
Thailand should start thinking and implementing measures to compete for potential population. and skilled workers coming into Thailand from today or not?
With best wishes
Panthep Puaphongphan
Dean of the College of Oriental Medicine, Rangsit University
refer
[1] Time, Special Health Double Issue, This Baby Could Live To Be 142, Dispatched from the Frontiers of Longevity
https://time.com/3706775/in-the-latest-issue-23/
[2] Max Roser, Esteban Ortiz-Ospina and Hannah Ritchie, Life Expectancy, Our World in Data, First published 2013; last reviewed in October 2019.
https://ourworldindata.org/life-expectancy
[3] Hannah Ritchie and Max Roser, Global distribution of smoking deaths, Our World in Data, first published May 2013; it was significantly revised in November 2019. The last update was made in August 2023.
https://ourworldindata.org/smoking
[4] AgelessRx, Participatory Evaluation (of) Aging (With) Rapamycin (for) Longevity Study (PEARL), Estimated Study Completion 2023-12
https://clinicaltrials.gov/study/NCT04488601
[5] BBC News Thailand, Manee Daeng: Discover a longevity elixir made by the people of Thailand. Hope to reverse old cells to make 75-year-olds look as young as 25, 13 July 2022
https://www.bbc.com/thai/thailand-62145481
[6] Supawan Pipitsombut, Chula Medical Development Crash! RED-GEM Molecules to Reverse Aging, Chulalongkorn University, 17 January 2022
https://www.chula.ac.th/cy/highlight/59580/
[7] Sakawdaurm Yasom, et al., Roles of DNA gaps produced by HMGB1 in DNA protection and reversal of aging biomarkers, FASEB BioAdvances, 28 February 2022
https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fba.2021-00131
[8] The Economist, Live to 120 Special Report on How to Slow Ageing, September 30th – October 6th 2023, page 9
[9] Office of the National Economic and Social Development Council, Population Development Plan for Long-Term National Development (2022-2037), November 2022
#humans #work #years #live #years
