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The Responsibility of a Supervisor: A Lesson Learned from Research on Mutant p53 G199V gained antiapoptotic function through STAT3 in Anaplastic Thyroid Cancer Cells

[The Human Story in Dr. Yoo Young-hyun’s Medical Paper]

Published on: 2023.11.23 09:50 | Views: 57

Reference: 17: Kim TH, Lee SY, Rho JH, Jeong NY, Soung YH, Jo WS, Kang DY, Kim SH, Yoo YH. Mutant p53 (G199V) gains antiapoptotic function through signal transducer and activator of transcription 3 in anaplastic thyroid cancer cells. Mol Cancer Res. 2009; 7: 1645-1654

■ Subject: Taehyeon Kim (third research professor)
■ Academic Significance: Identification of the mechanism by which the mutant p53 G199V acquires anti-cell death function

In a moving reflection on personal regret and professional accountability, Dr. Yoo Young-hyun shares a poignant story that underscores the complexities of mentorship and supervision in academic research.

Entering the world of academia, Dr. Yoo recounts the bittersweet experiences of her career, culminating in a moment of deep self-awareness and a sense of responsibility in her role as a supervisor. Reflecting on a past encounter with a student, Taehyeon Kim, she delves into the nuanced dynamics of mentorship and the delicate balance of guiding young scholars while holding them to a high standard of academic integrity and excellence.

As Dr. Yoo navigates the intricate process of steering her student through the challenging terrain of research publication, she grapples with the ethical implications of her decisions, ultimately realizing the importance of being a mentor who speaks truthfully – even when it is difficult.

In sharing her journey of growth and introspection, Dr. Yoo imparts a profound message of accountability and the fundamental duty of academic supervisors to guide, support, and challenge their students to reach their full potential. As she approaches retirement, Dr. Yoo’s reflections serve as a timeless reminder of the profound impact of mentorship and the enduring responsibility of nurturing the next generation of scholars.

[유영현의 의학 논문 속 사람 이야기]

Entered 2023.11.23 09:50 Views 57 Entered 2023.11.23 09:50 Modified 2023.11.23 09:13 Views 57

17: Kim TH, Lee SY, Rho JH, Jeong NY, Soung YH, Jo WS, Kang DY, Kim SH, Yoo YH. Mutant p53 (G199V) gains antiapoptotic function through signal transducer and activator of transcription 3 in anaplastic thyroid cancer cells. Mol Cancr Res. 2009; 7: 1645-1654

■ Person: Taehyeon Kim (third research professor)
■ Academic significance: Identification of the mechanism by which mutant p53 G199V acquires anti-cell death function

A woman in her 60s still can’t forget the fight she had with her mother at the college entrance exam window decades ago. At that time, her mother persuaded her daughter to apply to pharmacy school based on her academic achievement test scores. She insisted on going to the humanities department to keep the promise she made to her friend.

That day, the mother gave in to her daughter’s stubbornness. Afterwards, whenever she envied the qualifications that allowed her to live as an expert, she was full of regret, thinking, “It would have been nice if a mother had broken the will of a childish girl.”

He does not agree with the current philosophy that parents should let their children do whatever they want. She strongly criticizes the current situation where a daily newspaper article states, “Interfering with your child’s major and career path is like trying to commit suicide with your child.”

She lives by the belief that “adults should not hide the true story from those beneath them.” This paper teaches me the same lesson about the role of a supervisor.

Dr. completed Taehyun Kim his doctoral degree and was appointed as the third research professor in Naebang. I became his supervisor. In planning a highly influential study, a new mutation in p53 was discovered in thyroid cancer cells at the start of the study. The G199V mutation was registered in the gene bank.

p53 mutations registered in the gene bank. [사진=유영현 제공]Next, we studied the mechanism by which the G199V mutant resists cell death. The process of unraveling the mechanism of cell death mutation was not short. After four years of research, big data was collected.

When I started writing the paper, I decided that if I thought of two other key materials, it could be accepted into a ‘Cancer Res’ level magazine.

I asked Dr. Kim carefully.

I did not always give strong instructions to students and researchers, but I expressed my opinion carefully and asked what they wanted.

“Why not add research even if there is a delay before submitting the paper?”

Dr Kim did not respond readily. I understood that he, who had experienced the sense of freedom at the end of his long search, did not want to go back to it. I forgot my duties as a supervisor and accepted Dr Kim’s opinion.

When I submitted the written paper to ‘Cancer Res’, the leading cancer journal, the reviewers noted, as I expected, that “two data were missing.”

The paper was subsequently reviewed by several journals, but continued to be rejected for similar reasons. ‘Mol Cancer Res’ sent the result of a review stating that the addition of both analysis data would be conditionally adopted. Since I received the answer of ‘conditional adoption,’ I had no choice but to add two necessary analyses.

Every time I think about this paper, I blame Dr. Kim for the disappointing results of the paper.

However, I finally realized this while going through pre-retirement papers. It was my fault for not fulfilling my duties as a senior officer and deferring responsibility for the results to Dr. Kim. The attitude was not unlike that of the mother who accepted her daughter’s wishes at the college entrance exam window and the attitude of Pontius Pilate, who tried to break away from his sins by washing his hands.

A proper supervisor is one who speaks bitterly. However, as I am about to retire next February, I will never have the opportunity to properly serve as a supervisor again. Retire when you grow up.

#supervisor #speak #bitterly #Comedy.com

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