▲Research results have shown that type 2 diabetes and Alzheimer’s disease are related to each other. (Photo = DB)
[메디컬투데이=최재백 기자] Type 2 diabetes and Alzheimer’s disease have been shown to be linked.
Research findings showing a link between type 2 diabetes and Alzheimer’s disease were presented at the annual meeting of the American Society for Biochemistry and Molecular Biology.
A research team at Texas A&M University cited meta-analysis data showing that the risk of developing Alzheimer’s dementia in patients with type 2 diabetes is 56 percent higher than in people without diabetes. Since type 2 diabetes is related to eating habits and lifestyle, eating habits and lifestyle habits are related: it was expected that this could be an important factor in the progression to Alzheimer’s disease.
The research team explained that a high-fat diet suppresses the Jak3 protein in the gut, and that in mice lacking the Jak3 protein, inflammation begins in the gastrointestinal tract and progresses to the liver and brain, eventually developing symptoms similar to Alzheimer’s, including cognitive impairment.
They explained that the Jak3 protein causes intestinal permeability, which leads to low-grade inflammation and type 2 diabetes, and that dementia symptoms can appear when the brain’s ability to process toxic substances decreases. Leaky gut is a condition in which toxins and bacteria leak out of the gastrointestinal tract and into the blood through narrow spaces in the wall of the gastrointestinal tract.
The research team expected that through a healthy diet and blood sugar control they could prevent intestinal permeability and inflammation, ultimately preventing type 2 diabetes and Alzheimer’s disease.
They said it was too early to conclude a link between type 2 diabetes and Alzheimer’s disease at this time, but they predicted that the link between the two diseases would have similar effects in other types of dementia.
Meanwhile, experts have termed the relationship between type 2 diabetes and Alzheimer’s disease as type 3 diabetes.
They said this could affect the gut-brain axis since the liver, which makes hormones key to regulating blood sugar, is also involved in the digestive process, and that high blood sugar or insulin levels could cause damage to the brain, increasing the risk of Alzheimer’s disease.
They said that since the organ in the human body that requires the most energy is the brain, high or low blood sugar levels can damage the brain’s blood vessels and nerves, causing loss of memory, learning and mood control, as well as increased weight and hormonal changes.
[ⓒ 메디컬투데이. 무단전재-재배포 금지]
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