Incidence of cardiovascular diseases based on genetic risk and clinical risk. Graphics = Reporter Yujin Lee
Recently, as the incidence of acute cardiovascular disease increases every year due to the aging of the population, the results of a national study were revealed that can be used as a basis for predicting the onset of the disease in disease prevention.
Research results have shown that the incidence of cardiovascular diseases increases significantly depending on lifestyle habits such as smoking, obesity, hypertension, the presence of chronic diseases and genetic influences. It is expected that such data will be used as a practical indicator for disease prevention in the future.
Recently, the National Institute of Health, Korea Agency for Disease Control and Prevention, improved the cardiovascular disease risk prediction method currently used for clinical diagnosis and published new research results on disease risk prediction cardiovascular diseases tailored for Koreans in the peer-reviewed journal Frontiers in Genetics.
According to research findings, people who belong to high-risk groups based on clinical risk are 3.6 times more likely to develop cardiovascular disease than the general public.
Clinical risk is a calculation of the risk of developing cardiovascular disease within 10 years based on clinical information such as age, sex, smoking, hypertension and diabetes.
Furthermore, even if the clinical risk was low, the incidence increased approximately 1.5 times if the genetic risk was high.
Furthermore, among high clinical risk groups, if the genetic risk is also high, the increase in incidence increases up to five times.
This is a study conducted by the National Institute of Health to comprehensively evaluate the risk of developing cardiovascular disease by analyzing clinical data, genetic information, and 17-year follow-up outcomes for 7,612 community cohorts (statistically, a group with shared factors) during the Korean Genome Epidemiology Survey Project.
It was recently reported that the incidence of cardiovascular disease increases two to three times depending on genetic risk, but the Korea Agency for Disease Control and Prevention says that research on clinical risk and clinical usability of risk genetics currently used in clinical settings the practice is minimal. Here’s the explanation.
Unlike previous studies, this study used 17 years of follow-up information and is significant in that it was able to increase the accuracy of cardiovascular disease prediction when genetic information was integrated into clinical risk.
As a result, it is expected to be used as a scientific basis for predicting and preventing high-risk cardiovascular diseases tailored to Koreans.
A tool to predict the risk of developing cardiovascular disease using clinical information has already been developed in the United States, and early prevention measures such as medication suggestions and lifestyle changes are recommended for those in the high-risk group.
In Asia, including Korea, the results have not been sufficiently verified and are not included in medical guidelines.
Among them, according to the “Cardiovascular Disease Occurrence Statistics” of the Korea Disease Control and Prevention Agency, as of 2021, the number of myocardial infarctions and strokes in Korea increased by 54.5% and 9.5%, respectively compared to 2011, and Ulsan increased by 62.6% and 16.5%, respectively, the highest in the country. It significantly exceeded the average increase.
As the incidence of cardiovascular disease is increasing in Korea due to aging, the need for preventive disease prevention tools based on related research is highlighted. Journalist Min Chang-yeon changyoni@
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