The international academic journal Nature published as its cover this week an image of a mouse spinning in a chat wheel. The rat’s body has images representing its organs. On the left side of the cover you can also see the phrase “EXERCISE EFFECTS”.
It is well known that regular physical activity is good for your health. Active research has been conducted in academia to examine the positive effects of exercise on the body, but the mechanisms that occur in the exercising body at a molecular level have not been identified.
The ‘Molecular Transformation During Physical Activity Consortium (MoTrPAC)’, a research project hosted by the US National Institutes of Health (NIH), published the results of a study in Nature on 1 (local time) that confirmed various changes occurring in the body during resistance exercise at the molecular level through rat experiments announced
The research team observed rats exercising on a wheel for eight weeks. 48 hours after exercise, samples and blood were collected from 18 organs, including the heart and brain. To identify even the smallest changes occurring in the body, changes in the transcriptome, epigenome, proteome, metabolome, lipidome and body immune system were measured. The “multiomics” analysis method was used, which comprehensively analyzes different biological data.
The research team analyzed 9,466 biological data. As a result, long-term exercise has been found to cause changes in ribonucleic acid (RNA), proteins, and metabolites that act during protein synthesis based on genetic information. Through this, the mitochondrial pathway involved in cellular respiration, as well as the immune system, metabolic response and stress response were regulated. “These changes are linked to health conditions, including non-alcoholic fatty liver disease, inflammatory bowel disease, and recovery from cardiovascular tissue damage,” the research team explained.
The times at which the effects of exercise on the body appear differ depending on gender. For example, body fat decreased in male rats eight weeks after starting exercise, but no significant change in body fat percentage was found in female rats.
The research team said: “This is the first map of the body to examine the effects of exercise on each organ of the body” and added: “This study can be used to improve exercise habits for managing of diseases”.
#표지로 #읽는 #과학 #exercise #good #health #discovered #molecular #level #Donga #Science
