Whole-Food Diet vs. Macros for Cholesterol & Lipids
- At the National Lipid Association (NLA) Scientific Sessions in 2025, Alice H.
- Lichtenstein noted that extreme diets, such as very low-carb plans, might elevate triglyceride levels.
- According to Lichtenstein, diets higher in unsaturated fats compared to saturated fats demonstrably lower LDL-C levels and reduce CVD risk.
Prioritize whole foods over rigid macros for optimal lipid management and reduced cardiovascular risk. A recent study from the National Lipid Association emphasizes that dietary quality—rich in fruits,vegetables,and unsaturated fats—trumps strict macronutrient ratios. Prioritizing fiber-rich foods and plant-based fats can significantly improve cholesterol levels. News Directory 3 examines these findings, underscoring the importance of focusing on overall dietary patterns rather than percentages of fat, carbs, and protein. Discover what’s next as research evolves and refines guidance for patient health.
Dietary Patterns Key to Lipid profiles and Cardiovascular Risk
Updated May 29, 2025
At the National Lipid Association (NLA) Scientific Sessions in 2025, Alice H. lichtenstein, a senior scientist at tufts University, discussed the influence of dietary patterns and macronutrient composition on lipid profiles and cardiovascular disease (CVD) risk. She emphasized a focus on overall dietary quality rather than strict macronutrient ratios for effective lipid management.
Lichtenstein noted that extreme diets, such as very low-carb plans, might elevate triglyceride levels. She advocated for food-based dietary patterns rich in whole grains,fruits,vegetables,fish,low-fat dairy,legumes,and nuts. If meat is included, lean cuts and unprocessed options are best. Limiting added sugar and salt is also crucial for maintaining healthy lipid profiles and reducing cardiovascular risk.
According to Lichtenstein, diets higher in unsaturated fats compared to saturated fats demonstrably lower LDL-C levels and reduce CVD risk. She also highlighted the benefits of dietary fiber,found in unrefined grains,fruits,vegetables,legumes,and nuts. Fiber slows glucose absorption,positively alters gut microbiota,and promotes overall gastrointestinal health.

Lichtenstein advised pharmacists to recommend plant-based fats over animal sources and to encourage the consumption of fish and unprocessed meats. She stressed the importance of focusing on dietary patterns rather than obsessing over percentages of fat, carbohydrates, and protein.
focus on dietary patterns rather than macronutrient profiles. Talk about foods to include (eg, plant forward diet), and not percent of fat, carbohydrates, and protein, which is nearly impossible to accurately calculate.
Alice H. Lichtenstein, DSC
What’s next
Future research should continue to explore the nuanced effects of various whole-food dietary patterns on lipid metabolism and cardiovascular health, providing pharmacists with more specific guidance for patient counseling.
