Colon cancer is the second most common cancer in both men and women, but it has a high chance of being completely cured through early treatment, so not only early diagnosis but also prevention of recurrence after cancer treatment is considered important. Research findings reported that people who frequently drink coffee have a significantly lower risk of colon cancer recurrence.
Many studies have reported that coffee consumption is associated with a reduced risk of colon cancer. However, while an estimated 20-30% of colon cancer patients experience cancer recurrence, the relationship between coffee, one of the most consumed beverages in the world, and cancer progression was unknown. To study the relationship between coffee consumption and recurrence, defined as colon cancer recurrence or metastasis to other sites, a research team from Wageningen University in the Netherlands analyzed data from a prospective cohort study in which 1,719 patients with stage 1 to 3 colon cancer answered questions about their diet. Stage 4 patients were excluded because they included patients whose cancer had not healed and were therefore not eligible for the topic of recurrence in this study.
The results of the analysis showed that, compared to colorectal cancer patients who drank less than one cup of coffee per day, patients who drank more than five cups of coffee per day were 32% less likely to cancer recurrence within six years.
Furthermore, as a result of the analysis of the relationship between coffee drinking habits and the risk of death from all causes, those who consumed more than 5 cups of coffee per day had an overall mortality rate 29% lower than those who consumed 1 cup or less. and those who consumed 2 to 4 cups had a 38% lower mortality rate. In other words, the effect of coffee in reducing the risk of death reaches its maximum between 2 and 4 cups, and the risk of death increases slightly if you drink more than 5 cups.
As a result, the research team concluded that the optimal coffee intake is 3 to 5 cups per day and that drinking 4 cups of coffee reduces the risk of death.
Although this study did not distinguish between regular coffee and decaffeinated coffee, decaffeinated coffee is said to be not commonly consumed in the Netherlands. The relationship between coffee and longevity has been reported in many regions other than the Netherlands. For example, according to a study conducted in the United States in 2018, colon cancer patients who drank more than four cups of coffee a day had a 30% higher risk of death from all causes than patients who didn’t drink at all. coffee, and a 30% higher risk of death from colon cancer in all advanced stages, including stage 4. This was 52% lower.
Although the exact mechanism by which coffee prevents colon cancer recurrence has not been revealed, three possibilities have been suggested by research to date. First, coffee’s powerful antioxidant effect can prevent cancer by protecting cells from oxidative stress. Secondly, coffee consumption can promote cancer prevention and treatment effects by regulating the composition of intestinal microorganisms. Third, coffee consumption can prevent colon cancer metastasis by improving liver function in colon cancer patients and preventing non-alcoholic fatty liver disease, a risk factor for liver metastasis. Cancer metastasis from the colon to the liver is known to occur in 30% of colon cancer patients and accounts for more than half of colon cancer patient deaths.
The research team said that the causal relationship between coffee and cancer cannot be determined from this observational study, but that it will not only be useful in future interventional research, but will also serve as evidence to establish treatment guidelines for cancer patients colon cancer studied the mechanism by which coffee improves the prognosis of colon cancer and said more research is needed to fully understand it. Related information can be found here.
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