On June 17, 2023, Professor Dr Teerawat Hemajutha or “Doctor Theerawat” Director of the Emerging Diseases Health Science Center Chulalongkorn University Faculty of Medicine A private post on Facebook states that
- Too Much Vitamin B6, Nerve Inflammation
family doctors, especially psychiatrists andnervous system Become suspicious, observe and observe. abnormality ofnervethat cannot be explained by the absence of congenital disease chronic It is not emaciated, lack of food, or have liver disease, but rather have nervous symptoms. In the form of numbness, a burning sensation along the toes and fingers. Until the bones ache until the muscles are weak. and in some cases, muscle spasms Abnormal balance, staggering, and, so far, frequent urination, day and night, have been reported. and finally unable to urinate (The dose was used at 10 mg per day for three years) and the symptoms improved after stopping. for no other reason And there are more and more reports in neurological journals and toxicology centers.
That is, the effect or side effect that occurs from the supplement.vitamin B complex with the amount of Vitamin B6 in high doses by the doctor who prescribes it or the person who eats it may not know because it is a mixture of vitamins, minerals that are commonly sold and consumed by many brands, without warning about possible side effects Because in the early stages it is not clear how much it should be. Which is considered a water soluble vitamin. and can be excreted
the size of themultivitamin with B 6 Higher doses of 10 to 25 milligrams per day are needed as a therapeutic dose if necessary, such as when taking isoniazid for tuberculosis and when the side effects of isoniazid occur until seizures climb. and in pregnant women with severe vomiting (hyperemesis gravidarum) and in patients with abnormal conditions. Nutrition provides a high level of vitamins. reduce and cause neurological symptoms as well
In addition to isoniazid, there are other drugs such as cycloserine penicillamine. The Parkinson’s disease drug levodopa lowers vitamin B6 levels, and B6 is also used to treat magnesium deficiency.
for other reasons That must be supplemented with vitamin B 6 because in the elderly. Especially with congenital disease People often do not get enough B6 nutrients, and B6 is found in meat, liver, fish, beans and lentils. and foods that have been processed, stored and cooked will reduce their B6 content by 10 to 50%.
deficiency symptoms will be the same Vitamin B6 Too much to the point that it could cause confusion as to what exactly is being caused. This may require vitamin levels to be tested. in the blood along with other causes such as neurological symptoms Especially with numbness and burning caused by diabetes, underactive thyroid gland, HIV infection. infection with certain bacteria until syphilis An immune-mediated disease Abnormal bone marrow protein (monoclonal gammopathy), lymphoma, and drug toxicity, including cancer chemotherapy, heavy metal poisoning, organophosphorus pesticides
The usual daily dose of vitamin B6 is 0.5 to 1 mg in children, 1.3 mg in adolescents and adults, 1.7 mg in men over 50, and 1.7 mg in women over 50. 0.5 milligram size
in general, in order not to complicate for adult women or men The general dose is 1.9 milligrams per day. For people who are really elderly The dose can be higher but should not exceed 10 mg per day.
The mechanism of vitamin B6 toxicity is also dose dependent. and duration of eating May be with pyridoxal-5-phosphate dependent enzyme inhibition
In many countries such as Australia the use of vitamin B complex and B6 has been closely monitored, with the dose of vitamin B6 in all products reduced from 200 mg daily to no more than 100 mg per day in adults. and reduced size in children
On August 5, 2022, for example, of the 32 reported cases, 22 were confirmed to have high blood levels and 21 took vitamin B6 at a daily dose of 50 mg or less. In nine cases, it was found that a combination of products containing vitamin B6 had been used.
and with such side effects All products containing doses of B6 over 10 mg per day must be clearly labelled. about the dangers that can arise from nerve inflammation As published on October 4, 2022 (Australian Government. Department of Health and Aged Care/Therapeutic Goods Administration).
For the United States, the annexVitamin B6 Especially in the elderly, it will be in a dose of no more than 50 to 100 milligrams per week (American Journal of Therapeutics, November / December 2022).
At this point, don’t be afraid. Too many vitamins, because these vitamins are necessary for the body to grow. and repair worn out parts and in the food we eat every day By having to eat healthy food, but in elderly people, pregnant people or in abnormal conditions or using certain drugs together Vitamin supplements may be needed. but you must see the right size AND you must not add too much even though it is not necessary at all