Hypertensive patients with left ventricular hypertrophy showed the lowest rate of cardiovascular disease in the blood pressure range of less than 130 mmHg systolic and less than 80 mmHg diastolic.
The research team led by Hyunchang Kim, Hyukhee Lee, Hogyu Lee, Department of Preventive Medicine, Yonsei University College of Medicine, and Professor Seongha Park of the Department of Internal Medicine followed up 95,545 patients with left ventricular hypertrophy through electrocardiography during the 2004-2008 national health check-up for 12 years. The blood pressure range with the lowest incidence of cardiovascular disease was less than 130 mmHg systolic and less than 80 mmHg diastolic.
Hypertension is a common disease that affects 12 million people, about 30% of adults in Korea. Blood pressure control is essential to prevent cardiovascular complications. However, in the case of hypertension with left ventricular hypertrophy, if blood pressure is excessively lowered, blood does not flow to the enlarged heart muscle, which may increase the cardiovascular risk. To date, the optimal target blood pressure level that can prevent cardiovascular complications in this patient has not been accurately investigated.
A retrospective study of the association between blood pressure and the risk of cardiovascular disease using the Cox proportional hazards model found that the blood pressure range with the lowest cardiovascular disease incidence was less than 130 mmHg systolic and less than 80 mmHg diastolic. The Cox proportional hazards model is a tool to analyze risk factors affecting the incidence of disease, and can identify the risk of cardiovascular disease that increases as blood pressure increases.
As the systolic and diastolic blood pressures were higher than 130 mmHg and 80 mmHg, respectively, the incidence of cardiovascular disease also increased proportionally. When the systolic blood pressure was 140 mmHg or higher or 130 to 139 mmHg, the risk of cardiovascular disease was 31% and 8% higher, respectively, than when the blood pressure was 120 to 129 mmHg. In the case of diastolic blood pressure, the risk of cardiovascular disease was 30% and 6% higher when the blood pressure was higher than 90 mmHg or 80 to 89 mmHg, compared to the case when the blood pressure was 70 to 79 mmHg.
![[그림설명] The incidence of cardiovascular disease by blood pressure in the systolic and diastolic phases. It shows the lowest incidence in systolic less than 130 mmHg and diastolic less than 80 mmHg.](https://i0.wp.com/cdn.docdocdoc.co.kr/news/photo/202111/2016539_2020775_1910.jpg?resize=350%2C167&ssl=1)
On the other hand, a lower systolic blood pressure of less than 120 mmHg or a diastolic blood pressure of less than 70 mmHg did not reduce the risk of cardiovascular disease further.
Professor Hyunchang Kim explained, “This result shows that it is appropriate to set the target treatment blood pressure to be less than 130 mmHg systolic and less than 80 mmHg diastolic in hypertensive patients with left ventricular hypertrophy.”
He continued, “Left ventricular hypertrophy is a common disease in patients with long-standing hypertension, but there have been few studies on hypertension with left ventricular hypertrophy. It can be used as a standard for
Meanwhile, the results of this study were published in the latest issue of the Journal of the American College of Cardiology (IF 24.094), a renowned international academic journal in the field of cardiology.
