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Persistent Respiratory Symptoms after COVID-19 Increase Risk of New Asthma Cases, Study Shows

According to a recent study conducted by the National Health Insurance Corporation, it has been reaffirmed that individuals experiencing persistent respiratory symptoms after COVID-19 are at a higher risk of developing asthma. However, the research also highlights that receiving a COVID-19 vaccination can help prevent the onset of new asthma cases. The study, titled ‘Increased risk of new asthma after COVID-19 infection: Nationwide population-based cohort study,’ was published in the prestigious academic journal ‘Journal of Allergy and Clinical Immunology.’

COVID-19 has been known to exhibit asthma-like respiratory symptoms such as coughing, wheezing, and shortness of breath, even after recovery. Nevertheless, this is the first study to investigate whether these persistent respiratory symptoms are linked to the development of asthma. Previously, Professor Sang-heon Kim and his team conducted a study on 394 individuals experiencing respiratory symptoms after recovering from COVID-19 at Hanyang University Hospital. Their findings, published in a paper titled ‘New incidence of asthma in adults following COVID-19 infection,’ indicated a potential increased risk of acquiring asthma after COVID-19. In this latest paper, the research team further solidified the evidence through a national population-based cohort study.

The study aimed to determine if COVID-19 infection could contribute to an increase in new asthma cases and whether the COVID-19 vaccine could mitigate this risk. By utilizing the National Health Insurance Service big data, the team conducted three separate analyses. Firstly, they compared 44,023 individuals diagnosed with COVID-19 to a control group (Study 1). Secondly, they examined 139,740 individuals who were fully vaccinated with the COVID-19 vaccine and a control group (Study 2). Lastly, they analyzed 127,924 vaccinated individuals who did not receive a COVID-19 diagnosis and a control group (Study 3). Through these analyses, they assessed the risk of developing new asthma in each group.

The study revealed that the case group diagnosed with COVID-19 had a 2.1 times higher likelihood of being newly diagnosed with asthma compared to the control group. Conversely, the case group that received the COVID-19 vaccine demonstrated a significantly lower incidence of newly diagnosed asthma in comparison to the control group (approximately 0.8 times). It is important to note that both vaccinated and control groups, excluding those with COVID-19, exhibited no significant increase or decrease in new asthma cases.

Professor Kim Sang-heon emphasized the need for medical professionals to differentiate persistent respiratory symptoms lasting over four weeks after recovering from COVID-19, as it may indicate a higher risk of developing new asthma. He further reaffirms that this study reconfirms previous research’s findings regarding the possibility of developing asthma due to COVID-19. Additionally, Professor Kim highlights the positive impact of COVID-19 vaccination in reducing the likelihood of new asthma cases.

In conclusion, this study provides valuable insights into the association between COVID-19 and the subsequent development of asthma. The findings underscore the importance of addressing persistent respiratory symptoms and the potential benefits of COVID-19 vaccination in mitigating the risk of new asthma cases.

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Money Today Reporter Jeong Sim-gyo | 2023.10.20 11:29

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Previous research results showing that persistent respiratory symptoms after COVID-19 can increase the number of new asthma cases have been proven again with big data from the National Health Insurance Corporation. The results also revealed that a COVID-19 vaccination could prevent new asthma. The research team of Professor Sang-heon Kim, Hyun Lee, and Bo-geun Kim from the Department of Respiratory Allergy at Hanyang University Hospital published a paper titled ‘Increased risk of new asthma after COVID-19 infection: Nationwide population – based cohort study’ published in the September online edition of the famous international academic journal ‘Journal of Allergy and Clinical Immunology’. It was revealed this way.

COVID-19 shows asthma-like respiratory symptoms, such as coughing, wheezing, and shortness of breath, as long-term after-effects after recovery. However, until now, there has been no research into whether respiratory symptoms that persist after being infected with COVID-19 are associated with new cases of asthma. In relation to this, Professor Kim’s team previously conducted a study on 394 people complaining of respiratory symptoms after recovering from a COVID-19 infection at Hanyang University Hospital, and published a paper titled ‘New incidence of asthma in adults on post infection of COVID-19’, which found new asthma after the onset of COVID-19 Results have shown that the likelihood of occurrence may increase. In this paper, we strengthened the evidence on new cases of adult asthma after COVID-19 infection through a national population-based cohort study.

In this paper, Professor Kim’s team studied whether COVID-19 can increase the number of new asthma cases and whether the COVID-19 vaccine reduces the number of new asthma cases. By 1:1 matching using National Health Insurance Service big data, 44,023 cases and a control group (Study 1) diagnosed with COVID-19, 139,740 cases who were fully vaccinated (2 times or more) with the COVID-19 vaccine A control group (Study 2), 127,924 vaccinated cases excluding those diagnosed with COVID-19, and a control group (Study 3) were selected to compare and analyze the risk of develop new asthma, respectively.

As a result of the study, in the case group diagnosed with COVID-19, the number of patients newly diagnosed with asthma was 2.1 times higher than in the control group. The case group that received the COVID-19 vaccine had a significantly lower number of newly diagnosed asthma patients than the control group (about 0.8 times), and both the vaccinated case group and the control group showed except for the cases diagnosed with COVID-19 increase/decrease in new asthma and it was confirmed that there was no significant association.

Regarding this study, Professor Kim Sang-heon said, “Previous research has confirmed that if asthma-like respiratory symptoms persist for more than 4 weeks after recovery from COVID-19, the risk of developing new asthma can be high and expert examination needs to differentiate.” “I did,” he said.

Professor Kim also said, “In this study, we reconfirmed the possibility of new cases of asthma due to COVID-19, which was confirmed in previous studies through a national population-based cohort,” and added, ” Cases who were fully vaccinated against COVID-19 -19 better than those who were not vaccinated.” “It was also revealed that the possibility of developing new asthma is significantly low.”

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