[금강일보 박정환 기자] The National Research Foundation of Korea (Chairman Kwang-bok Lee) announced on the 21st that a research team led by Professor Han Jin and Professor Kim Hyung-gyu (Center for Cardiovascular and Metabolic Diseases, Inje University) has identified a new function of the Cereblon protein that regulates the electrical activity and contractile force of the heart.
The research team confirmed that the expression of the cereblon gene was increased in the heart of patients with heart failure, and based on this, created a genetically engineered mouse model in the heart. the mechanism was elucidated. This was confirmed to be the cause of the decrease in the function of the calcium channel, which is involved in regulating the contractility of the heart in patients with heart failure.
Also, for the first time, a disease association was found: mice with lower cereblon expression had better heart contractility and resistance to heart disease. Professor Kim said, “There has been no clear standard system for the treatment of heart failure (HFrEF) with reduced left ventricular ejection fraction,” said Professor Kim.
By Park Jeong-hwan, staff reporter pjh@ggilbo.com
Send articles on social media
