[유영현의 의학 논문 속 사람 이야기]
Posted on 01.31.2024 15:00 Posted on 01.31.2024 15:00 Modified on 01.31.2024 14:18 Views 171
Chapter 27: Kim HY, Kwon WY, Kim YA, Oh YJ, Yoo SH, Lee MH, Bae JY, Kim JM, Yoo YH. Insulin resistance induced by polychlorinated biphenyl exposure is mediated by lipid droplet enlargement through Fsp27. Arcotoxic. 2017;91:2353-2363
■People: Professor Deokhee Lee (Kyungpook National University School of Medicine), Dr. Hyeyoung Kim (sixth research professor)
■Academic Importance: The first article to reveal the mechanism of insulin resistance caused by POPs
One day I participated as a reviewer on a research project and listened to the presentation of the candidate, Professor Deokhee Lee of Kyungpook National University. Professor Lee presented epidemiological evidence that persistent organic pollutants (POPs) distributed on Earth induce metabolic diseases, including type 2 diabetes. The presentation lit a spark in me.
A pioneering article by Professor Deokhee Lee (Kyungpook National University School of Medicine) supporting a link between POP and insulin resistance. [사진=유영현 제공]Having only current knowledge about environmental hormones, I searched for the relevant information. After reading related academic articles, my shock doubled. Concerns have been growing about the grim civilization caused by synthetic chemicals that have been distributed on Earth for more than 100 years. After a brief shock, attention was drawn to the lack of cellular and molecular biology research on POPs.
Previous experimental studies have revealed cause and effect only through simple studies. Despite extensive epidemiological evidence, prior to this study, only three experimental studies had examined whether POPs cause insulin resistance. Due to the delay in proving this through modern science, it was felt that only epidemiologists and environmental scientists were pointing this out, while mainstream medical scholars were ignoring it.
I suggested to Dr. Hyeyoung Kim that he immediately begin experimental research on the effects of POPs on human metabolism. In this study conducted to reveal the mechanism of action of POPs-induced insulin resistance, Dr. Hyeyoung Kim used cellular molecular biology methods to obtain research results demonstrating that POPs cause insulin resistance through Fsp27.
I also collected “direct evidence” to verify my interpretation using experimental data. Direct evidence is data that demonstrates the role of an agent involved in the phenomenon I observed through genetic manipulation or drug administration. Direct evidence can be obtained by deleting a gene and observing the loss of the phenomenon, or by overexpressing the gene and observing the intensification of the phenomenon.
In the past, POP researchers did not present such data. We have gained confidence in the value of this study with the newly obtained data.
Is this “toxicological” research or “diabetes” research?
I immediately submitted the article to Diabetes, the most authoritative magazine on diabetes. The reviewers raised no objections to the paper materials. However, the publisher refused to publish the article, stating: “Insulin resistance and high blood glucose levels do not define diabetes.”
Most mainstream diabetes researchers do not accept the explanation of insulin resistance due to environmental toxins. My thesis also met with resistance from mainstream medical scholars. According to them, my research was only a toxicology study and not a diabetes study.
I submitted an article to Arch Toxicol, the leading toxicology research journal that recognizes single compound administration studies. And first of all I was happy to see its toxicological value recognized.
Although it has only been published in one toxicology journal, this is a start. This article’s assertion that POPs induce diabetes adds important data to question the current paradigm for explaining diabetes. The fervor of a scientific revolution is also awakening in diabetes research.
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