Italian research group “Patients taking long-term drugs have fewer tumor metastases and better immunity.”
Research has shown that aspirin, which many people take for its anti-inflammatory and blood-clotting effects, prevents the development and progression of colon cancer by detecting tumor cells in the immune system and strengthening the immune response.
On the 23rd, Dr. Marco Scarpa’s team from the University of Padua, Italy, discovered this fact by studying the effect of long-term aspirin use on colon cancer using tissue samples from 230 patients undergoing surgery for American Cancer Society (ACS) colon cancer. revealed the academic journal Cancer.
Dr Scarpa said: ‘Taken aspirin is absorbed to a significant extent in the large intestine through passive diffusion’ and added: ‘The results of this study show that aspirin has a complementary mechanism for prevention or treatment of cancer in addition to the classic drug mechanism of suppression of inflammation”.
Many research findings have shown that aspirin, a nonsteroidal anti-inflammatory drug, prevents various cancers.
Furthermore, taking aspirin daily for a long period of time is known to reduce the incidence and mortality rate of colon cancer, but the exact mechanism of action has not been revealed.
The research team explained that in this study they analyzed the effects of aspirin on the tumor microenvironment, systemic immunity, and healthy mucosa surrounding the cancer using tissue samples from patients undergoing colon cancer surgery.
They collected tissue samples from 238 patients who underwent colon cancer surgery between 2015 and 2019, compared tissue differences between long-term aspirin users (12%) and the remaining non-users, and identified genes that they appear when colon cancer cells are exposed to aspirin. The expression, etc. were analyzed.
As a result, tissue samples from long-term aspirin users showed fewer tumor metastases to the lymph glands and a higher level of tumor infiltration by immune cells than those from non-aspirin users.
Additionally, experiments in which colon cancer cells were exposed to aspirin showed increased expression of the CD80 protein gene, which detects the presence of tumor-related proteins in some immune cells and alerts other immune cells.
The research team also explained that aspirin users showed a higher CD80 expression rate in healthy rectal mucosal tissue compared to non-users, which also suggests that aspirin aids the system’s tumor surveillance function. immune.
Dr. Scarpa said: “The concentration of aspirin absorbed can be very different depending on the location in the colon” and “To exploit the effect of aspirin against colon cancer, we need to think about how to ensure that the aspirin reaches the colon in an instant.” appropriate dose and is effective.” “It has to be done,” he said.
◆ 출처: Cancer, Marco Scarpa et al., “IMMUNOREACT 7: Regular aspirin use is associated with activation of immune surveillance in colorectal cancer,” http://doi.wiley.com/10.1002/cncr .35297
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