Vitamin D has been shown to increase the effectiveness of cancer treatment by improving the gut microbial environment. Photo source: Getty Images. Getty image number: 1367399640
Research results have shown that vitamin D increases the effectiveness of cancer immunotherapy by regulating intestinal microorganisms. On the contrary, a national study showed that when the concentration of vitamin D in the body is low, indicators linked to chronic diseases such as obesity, hypertension, dyslipidemia and fatty liver worsen. It is underlined that if you stay indoors for a long time you may have a vitamin D deficiency, so you need to expose yourself to sunlight for at least 5 minutes a day.
Dr. Evangelos Giampazolias’ research team at the University of Manchester Cancer Research Center in the UK has confirmed through animal experiments that vitamin D increases intestinal microorganisms that have anti-tumor effects, they announced in the international academic journal “Science ” on the 25th (local). time). .
It is known from previous studies that vitamin D participates in the intestinal microflora and helps regulate immunity. It is said to be associated with improved treatment efficacy of immune checkpoint inhibitors, which are cancer immunotherapy drugs, and reduced cancer incidence and mortality rates. Intestinal microflora refers to the entire community of microorganisms in the intestine. However, it is unclear how vitamin D changes the gut microbial environment or enhances the effect of cancer immunotherapy.
The research team confirmed the relationship between vitamin D, intestinal microorganisms and cancer immunotherapy through animal experiments. The bioavailability of vitamin D was increased by controlling genes and diet in experimental mice. Bioavailability refers to the rate at which an administered ingredient is absorbed into the circulating bloodstream.
Consequently, when the bioavailability of vitamin D increases, the intestinal microflora changes in such a way as to favor the gram-negative anaerobic bacterium “Bacteroides fragilis”. This bacterium is a microorganism that exists in both mice and humans. With the increase in Bacteroides fragilis, resistance to melanoma development occurred and the response to immune checkpoint inhibitors improved.
The research team also confirmed that when feces from mice with enhanced immunotherapy effects against cancer due to changes in the intestinal microflora were transplanted into other mice, the cancer immunity of the transplanted mice was also strengthened. The research team said: “This has not yet been confirmed through animal experiments, but humans also have Bacteroides fragilis” and added: “It is analyzed that the regulation of intestinal microorganisms through vitamin D has the potential to increase the effectiveness of cancer immunotherapy in humans”. Also.” .
A recent analysis showed that vitamin D deficiency helps manage chronic diseases. The research group of Hyeryeong Yoon, professor in the Department of Laboratory Medicine at Ansan University Hospital in Korea, confirmed that the lower the concentration of vitamin D, the higher the levels of indicators linked to chronic diseases such as obesity, high blood pressure, dyslipidemia and fatty liver and won an excellent award at the recent spring conference of the Korean Society of Diagnostic Immunology. He received an award for his thesis. Chronic disease indicators include waist circumference, body mass index, blood pressure and total cholesterol, and as these values increase, the risk of developing chronic disease increases.
To replenish vitamin D, you need time in sunlight. If you receive sunlight through a window indoors, vitamin D may not be synthesized properly, so you should go outside and receive direct sunlight for 5 to 30 minutes a day. People who have difficulty doing outdoor activities during daylight hours due to the nature of their work can take vitamin D supplements. However, if you are not vitamin D deficient, taking vitamin D supplements is not recommended. That’s because there are academic reports that an overdose of vitamin D increases the risk of fractures, and intake mixed with calcium increases the risk of heart disease.
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