[유영현의 의학 논문 속 사람 이야기]
Posted 2024.01.10 16:00 Views 23 Posted 2024.01.10 16:00 Modified 2024.01.09 09:19 Views 23
Section 24: Kim HY, Park SY, Lee MH, Rho JH, Oh YJ, Jung HU, Yoo SH, Jeong NY, Lee HJ, Suh S, Seo SY, Cheong J, Jeong JS, Yoo YH. Hepatic STAMP2 alleviates high-fat diet-induced hepatic steatosis and insulin resistance. J Hepatol. 2015;63:477-485.
■Person: Hyeyoung Kim (research professor)
■ Academic Significance: The Role of STAMP2 in High-Fat Diet-Induced Hepatic Steatosis
In my late twenties I pioneered the field of “cell death” and had already achieved some level of success, but the winds of disruption blew again. This was around the early 1950s.
Dr. Hyeyoung Kim, who joined my room as the sixth research professor, wanted to conduct research on lipid metabolism. If I accepted this proposal, the focus of my laboratory’s experiments should shift to lipid metabolism research using animal models, which induces fatty liver disease with a long-term lipid-rich diet.
When I started researching cell death, more changes were needed than when I transformed from a morphology researcher to a cell and molecular biology researcher. I didn’t have the confidence to undertake research that was incomparably more complicated than previous cell death research.
A conflict arose. But I decided to trust Dr. Kim. Dr. Hyeyoung Kim had good experience in research at the molecular level under the guidance of her molecular biology advisor.
I proposed, following my laboratory policy, to study the toxicity of lipids in a reservoir called cell death. This was a somewhat unreasonable proposition since lipids are not highly toxic. Dr. Kim accepted this unreasonable proposal, and my room began conducting “high-risk, but high-value” lipid toxicity research.
Cell death is pushed backwards and lipid metabolism shifts forward.
A completely different study from the main research conducted so far in my laboratory has begun. Once research began, research into cell death due to lipid toxicity was put aside and attention was focused on studying abnormalities in lipid metabolism. From that moment on, my principle of “conducting research while swimming in the tank of cell death” was no longer followed.
However, the data produced was so interesting and valuable that I became helplessly involved in this research. My studies have also extended beyond the reservoir of cell death and into the area of lipid metabolism.
When significant data was added, I began writing the paper even though the data was not fully available, allowing Dr. Kim to focus on the experiments without the burden of writing the paper.
On days when the results of animal tests were obtained, which took a long time, all 10 people in my laboratory were mobilized to analyze blood and collect tissue from dawn to night. There was applause when the mouse’s stomach was opened. Clear data was provided to prove our hypothesis.
This article was submitted to “J Hepatol”, the leading journal in the liver field, and was accepted without modification and recognized for its value. The thesis was also recorded in Hanbitsa (The People Who Make Korea Shine).
Dr. Kim received the Amore Pacific “Next Generation Researcher Award” for this article. For this article I received the Uidang Academic Award, awarded to a professor of basic medicine nationwide. I don’t study to win awards, but my results shine brighter when I receive them.
Dr. Hyeyoung Kim (second from left) attends the Amorepacific Next Generation Researcher Award ceremony. [사진=유영현 제공]
Kim Hye-young, who changed the theme of the workshop… However, the “Seposa” tank remains.
Subsequently, lipid metabolism research became the main research field in my room, and until the end of the research I mainly produced results in the field of lipid metabolism.
After I switched from cell death research to lipid metabolism, many fellow researchers asked me why I abandoned cell death research and switched to metabolism research. In an era when research on cell death was rare, an answer was lacking.
However, while conducting research on lipid metabolism, I did not burst the dam of the reservoir of cell death research. Subsequent research into lipid metabolism included research into cell death caused by lipid toxicity, and eventually my reservoir of “cell death” research was maintained.
When I began researching the mechanisms of cell death in the mid-1990s and when I began studying lipid metabolism in the early 2010s, it was a turning point in my research that included both crises and opportunities. If I had to interpret it, I got through this step well because I didn’t try to protect my identity and I showed a flexible attitude.
However, perceptions and actions regarding identity or flexibility do not produce results. Looking back, I made it through both periods by inexplicable luck. Research is also one of the three Luck skills!
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