The Link Between Bronchial Constriction and Lung Inflammation in Asthma Patients

Damage to the lining of the airways caused by bronchial constriction causes worsening of inflammation.

Posted on 04.06.2024 at 7.00pm Posted on 04.06.2024 at 7.00pm Modified on 04.06.2024 at 6.17pm Views 41

There are 5.4 million people in the UK with asthma. They may experience symptoms such as wheezing, coughing, difficulty breathing, and tightness in the chest. Pollen, dust and pet dander worsen symptoms and suffer life-threatening asthma attacks. [사진=게티이미지뱅크]Most current treatments for asthma are based on the idea that asthma is an inflammatory disease. Through analysis of lung tissue samples from mice and humans, researchers at King’s College London (KCL) in the United Kingdom have found that lung damage due to asthma is not caused by inflammation but by damage to the lining of the lungs. airways caused by bronchoconstriction. This is what the BBC reported on the 5th (local time) based on an article published in Science.

Professor Jody Rosenblatt, a professor of cell biology at KCL who led the study, said bronchoconstriction, which causes compression and tension of the smooth muscles surrounding the airways, damages the lining of the airways, causing long-lasting inflammation. term, healing of wounds and further attacks. Still. He explained: “Until now, this damage to the lining has been overlooked” and “This epithelial layer is the body’s first line of defense against infections, so damage to this line of defense causes a vicious cycle in which the inflammatory response it gets worse.”

There are 5.4 million people in the UK with asthma. They may experience symptoms such as wheezing, coughing, difficulty breathing, and tightness in the chest. Pollen, dust and pet dander worsen symptoms and suffer life-threatening asthma attacks.

Although it is a common disease, the cause of asthma is not yet known. The drugs and inhalers currently used only break down the sticky mucus blocking the airways, open the airways and soothe inflammation, but do not help prevent asthma.

This study suggests that the answer to stopping these asthma symptoms may lie in cell extrusion, which induces the death of most epithelial cells. The researchers found that when bronchoconstriction occurs, the epithelial cells lining the airways become compressed and subsequently die. When the bronchi narrow, they push out many cells, damaging the lining of the airways, causing inflammation and excess mucus.

The researchers found that the element gadolinium (element number 64) has a preventive effect, at least in mice. But there is still a lot of work to do and it will take many more years before we know whether it is safe and effective enough to be tested in humans.

Dr Samantha Walker, director of Asthma and Lung Research and Innovation UK, said: “This discovery opens important new doors to explore possible new treatment options that are desperately needed for people with asthma.” “We know there are many people for whom existing asthma treatments don’t work,” she said, “so it’s important to continue funding research to find new treatments that can better address the causes of asthma.”

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