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Understanding and Treating Neurodegenerative Hand Tremors: The Evolution of Ultrasound Surgery

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■ Lee Eun-jeong, professor of neurosurgery at Seoul National University Hospital
15% of people over the age of 65 experience neurodegenerative hand tremors
It gets worse as you get older, starting from middle age … Interference with social life
Ultrasound surgery, non-invasive… Quick return to everyday life, high preference

As people reach middle age, many people complain of ‘tremor syndrome’, a condition where hands shake regardless of their will. Today’s Image

‘Hypertremia’, a condition in which hands tremble involuntarily, is one of the most common movement disorders. In particular, as people reach middle age, more and more people suffer from tremors. Hand tremors make it difficult to make fine hand movements, interfering with everyday activities such as writing, signing, or eating. As a result, it can lead to bigger problems, such as difficulties in social life and depression.

If hand tremors persist chronically, brain dysfunction may be the cause. A representative example is hand tremors caused by ‘essential tremor’. If you have essential tremor, your hands will shake when you make movements in the air. The neural circuit involved in fine motor control is abnormally activated, causing tremors. On examination of the patient’s brain tissue, neurodegeneration is seen as a decrease in cucumber cells, axonal swelling, and degeneration of dentate nuclei often in the cerebellum. It can be seen that the ‘cerebellum’ plays an important role in essential tremor.

This type of neurodegeneration generally begins in middle age and worsens with age. It is estimated that approximately 15% of the population over the age of 65 in Korea experience neurodegenerative hand tremors. As neurodegeneration progresses and resistance decreases due to muscle weakness, symptoms worsen and, in severe cases, may be accompanied by tremors in the head, jaw and voice. Many patients suffering from these symptoms find it difficult to participate in social activities and interpersonal relationships. Some patients believe that hand tremors are part of the aging process and stop seeking treatment, but with a correct diagnosis and appropriate treatment, the symptoms of hand tremors can be adequately alleviated. In addition to essential tremor, the causes of hand tremors are varied, including Parkinson’s disease, other movement disorders such as dystonia, hyperthyroidism, electrolyte disorders, metabolic disorders including hypoglycemia, and drug side effects. Therefore, the causative disease must be identified and drug treatment given through treatment by a neurologist or neurosurgeon. About two-thirds of patients with essential tremor experience symptom improvement with drug treatment. Even if the results of the treatment are unsatisfactory, the effect can be improved by changing the drug or adjusting the dose.

A hemispherical helmet used during ultrasonic surgery. Photo provided by Seoul National University Hospital

The other third do not respond to treatment or develop resistance, making it difficult to control symptoms with drug treatment alone. In this case, stereotactic brain surgery is performed to locally degenerate tissue or control nerve activity by targeting the ‘thalamic nucleus’ among the neural circuits associated with tremors. Surgery is divided into four types: high frequency thermocoagulation, deep brain stimulation, radiosurgery, and ultrasonic surgery. Tremor symptoms are known to improve by an average of 70-80% compared to pre-surgery, and quality of life improves significantly.

High frequency thermocoagulation and deep brain stimulation are treatments that make small holes in the skull, insert electrodes, and control nerves through thermal denaturation or electrical stimulation. The effect is excellent, but since it is an invasive operation, complications such as brain hemorrhage and infection can occur in rare cases. In particular, if you have had deep brain stimulation using a rechargeable battery, it needs to be replaced every 15 years. Radiosurgery is a method of irradiating high doses of radiation to nerve targets. It has the advantage of being non-invasive, but since the target location can only be set using magnetic resonance (MR) images, accuracy is low and neurological sequelae such as brain edema can occur due to radiation effects. In addition, because the effect of the treatment appears several months later, it is difficult to confirm immediately whether the symptoms have improved.

The most recently developed ultrasonic surgery treats symptoms by wearing a hemispherical helmet with 1,024 ultrasonic piezoelectric elements arranged in it, and delivering the ultrasonic energy emitted from the elements to the target to coagulate the tissue with local heating. The shape of the lesion and the location of the introduction of ultrasound can be monitored in real time during the operation, so accuracy is high, and since it is a non-invasive operation that only requires local anesthesia, it is possible to quickly return to everyday life . The effect of the treatment is immediate and is currently the most preferred method for treating hand tremors. However, there are cases where ultrasonic surgery is not possible depending on the thickness or density ratio of the skull. Suitability for ultrasound surgery is evaluated by cranial computed tomography (CT) images.

In order to alleviate the symptoms of hand tremors, it is best to limit the caffeine taken during daily life and make efforts to improve the quality of sleep. It is also recommended to relax and manage stress through regular exercise, and to eat foods rich in antioxidants, such as vitamins C∙E and coenzyme Q, which are known to reduce the risk of neurodegenerative diseases. A representative example is the ‘Mediterranean diet’, which is considered a synonym for healthy food. Alcohol causes brain cells to deteriorate, so it is best to avoid drinking.

Eunjung Lee, professor of neurosurgery at Seoul National University Hospital. Photo provided by Seoul National University Hospital
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■ Lee Eun-jeong, professor of neurosurgery at Seoul National University Hospital
15% of people over the age of 65 experience neurodegenerative hand tremors
It gets worse as you get older, starting from middle age … Interference with social life
Ultrasound surgery, non-invasive… Quick return to everyday life, high preference

As people reach middle age, many people complain of ‘tremor syndrome’, a condition where hands shake regardless of their will. Today’s Image

‘Hypertremia’, a condition in which hands tremble involuntarily, is one of the most common movement disorders. In particular, as people reach middle age, more and more people suffer from tremors. Hand tremors make it difficult to make fine hand movements, interfering with everyday activities such as writing, signing, or eating. As a result, it can lead to bigger problems, such as difficulties in social life and depression.

If hand tremors persist chronically, brain dysfunction may be the cause. A representative example is hand tremors caused by ‘essential tremor’. If you have essential tremor, your hands will shake when you make movements in the air. The neural circuit involved in fine motor control is abnormally activated, causing tremors. On examination of the patient’s brain tissue, neurodegeneration is seen as a decrease in cucumber cells, axonal swelling, and degeneration of dentate nuclei often in the cerebellum. It can be seen that the ‘cerebellum’ plays an important role in essential tremor.

This type of neurodegeneration generally begins in middle age and worsens with age. It is estimated that approximately 15% of the population over the age of 65 in Korea experience neurodegenerative hand tremors. As neurodegeneration progresses and resistance decreases due to muscle weakness, symptoms worsen and, in severe cases, may be accompanied by tremors in the head, jaw and voice. Many patients suffering from these symptoms find it difficult to participate in social activities and interpersonal relationships. Some patients believe that hand tremors are part of the aging process and stop seeking treatment, but with a correct diagnosis and appropriate treatment, the symptoms of hand tremors can be adequately alleviated. In addition to essential tremor, the causes of hand tremors are varied, including Parkinson’s disease, other movement disorders such as dystonia, hyperthyroidism, electrolyte disorders, metabolic disorders including hypoglycemia, and drug side effects. Therefore, the causative disease must be identified and drug treatment given through treatment by a neurologist or neurosurgeon. About two-thirds of patients with essential tremor experience symptom improvement with drug treatment. Even if the results of the treatment are unsatisfactory, the effect can be improved by changing the drug or adjusting the dose.

A hemispherical helmet used during ultrasonic surgery. Photo provided by Seoul National University Hospital

The other third do not respond to treatment or develop resistance, making it difficult to control symptoms with drug treatment alone. In this case, stereotactic brain surgery is performed to locally degenerate tissue or control nerve activity by targeting the ‘thalamic nucleus’ among the neural circuits associated with tremors. Surgery is divided into four types: high frequency thermocoagulation, deep brain stimulation, radiosurgery, and ultrasonic surgery. Tremor symptoms are known to improve by an average of 70-80% compared to pre-surgery, and quality of life improves significantly.

High frequency thermocoagulation and deep brain stimulation are treatments that make small holes in the skull, insert electrodes, and control nerves through thermal denaturation or electrical stimulation. The effect is excellent, but since it is an invasive operation, complications such as brain hemorrhage and infection can occur in rare cases. In particular, if you have had deep brain stimulation using a rechargeable battery, it needs to be replaced every 15 years. Radiosurgery is a method of irradiating high doses of radiation to nerve targets. It has the advantage of being non-invasive, but since the target location can only be set using magnetic resonance (MR) images, accuracy is low and neurological sequelae such as brain edema can occur due to radiation effects. In addition, because the effect of the treatment appears several months later, it is difficult to confirm immediately whether the symptoms have improved.

The most recently developed ultrasonic surgery treats symptoms by wearing a hemispherical helmet with 1,024 ultrasonic piezoelectric elements arranged in it, and delivering the ultrasonic energy emitted from the elements to the target to coagulate the tissue with local heating. The shape of the lesion and the location of the introduction of ultrasound can be monitored in real time during the operation, so accuracy is high, and since it is a non-invasive operation that only requires local anesthesia, it is possible to quickly return to everyday life . The effect of the treatment is immediate and is currently the most preferred method for treating hand tremors. However, there are cases where ultrasonic surgery is not possible depending on the thickness or density ratio of the skull. Suitability for ultrasound surgery is evaluated by cranial computed tomography (CT) images.

In order to alleviate the symptoms of hand tremors, it is best to limit the caffeine taken during daily life and make efforts to improve the quality of sleep. It is also recommended to relax and manage stress through regular exercise, and to eat foods rich in antioxidants, such as vitamins C∙E and coenzyme Q, which are known to reduce the risk of neurodegenerative diseases. A representative example is the ‘Mediterranean diet’, which is considered a synonym for healthy food. Alcohol causes brain cells to deteriorate, so it is best to avoid drinking.

Eunjung Lee, professor of neurosurgery at Seoul National University Hospital. Photo provided by Seoul National University Hospital

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