Posted on 04.12.2024 at 08.30 Posted on 04.12.2024 at 08.30 Modified on 04.11.2024 at 20.32 Views 3
[사진=더쿠]Recently, diagnostic tests for dementia have become a hot topic in the community. If you can’t answer more than 10 questions correctly by guessing the pet’s name by looking at the initial 15 consonants, you are in the early stages of dementia. Although it has been circulating on the Internet for a long time, this test is actually related to brain training rather than dementia. The “Brain Training Method”, published in a newspaper in 2005, has been circulating on the Internet for 9 years. However, the fact that such a diagnostic test is a hot topic among people may mean that interest in dementia is high.
Dementia has long been considered a disease feared by people, but the incidence rate is actually increasing. According to an announcement from the Central Dementia Center, the estimated prevalence of dementia among seniors aged 65 and older last year was 10.41%. It is estimated that 1 in 10 people suffer from dementia. It is predicted that one in six people will be affected by dementia by 2050.
It is said that no one is exempt from dementia, but people with poor memories need to be more careful. Additionally, if you suddenly feel that your memory has diminished or your judgment has become clouded, you should start managing the situation immediately. In fact, it is known that there is a very high correlation between memory decline and dementia, with 80% of mild cognitive impairments converting to dementia within 5 years.
Dementia is something everyone fears. Why do we suffer it?
The main cause of Alzheimer’s dementia, which accounts for 70-80% of all dementia, is said to be a protein called “beta-amyloid.” Beta-amyloid is a toxic substance released when nerve cells in the brain exchange chemical signals. This is easy to understand if you think of byproducts as those produced when a factory is operating.
The glymphatic system operates in the brain while you sleep. [사진=코메디닷컴 DB]In fact, under normal circumstances, beta-amyloid should be removed through the “glymphatic system”, the cleaning system of our brain. The glymphatic system refers to a system in which melatonin, contained in the cerebrospinal fluid, cleans various waste products accumulated between brain cells during sleep.
However, if the glymphatic system is not functioning properly due to lack of sleep, etc., and beta-amyloid continues to accumulate between synapses, the neurotransmitters are prevented from moving to the next synapse. So, if the accumulated amount increases and exceeds the limit, the nervous system is eventually destroyed. This is the point at which the symptoms of dementia appear on the surface.
Suddenly one day? The dementia started 20 years ago
It is known that dementia is a disease that usually takes 20 years before symptoms appear. Although beta-amyloid residues continue to accumulate in the brain, no particular symptoms appear unless they reach a certain level. For this reason, if dementia occurred around age 65, the accumulation of beta-amyloid is believed to have begun around age 45, when there were no symptoms.
Although beta-amyloid, a substance that causes dementia, continues to accumulate in the brain, no significant symptoms appear on the outside. [사진= Alzheimer’s Research & Therapy volume 2, Article number: 23 (2010)]According to current research findings, amyloid beta continues to accumulate even before forgetfulness or mild cognitive impairment appears. This means that just because you don’t have any symptoms right now doesn’t mean you’re safe from dementia. In particular, if memory decline occurs even when you are young, it could be a sign that beta-amyloid is already accumulating in the brain, so efforts should be made to increase the brain’s housekeeping function.
The first rule to prevent dementia is good sleep habits.
This is why getting a good night’s sleep is important to prevent dementia. If you don’t sleep well, melatonin can’t do its job, increasing the likelihood of beta-amyloid buildup. In particular, 70% of total daily melatonin secretion is secreted between 11pm and 3am, and secretion reaches its maximum level between 2am and 3am. Therefore, going to bed at 11pm and waking up at 7am is the ideal sleep time to maintain the proper functioning of the glymphatic system.
However, it is not easy for modern, busy people to go to bed at 11pm and sleep for a full eight hours. In this case it is better to integrate melatonin also from the outside. Taking melatonin orally also helps expel beta-amyloid from the brain and aids the survival of nerve cells.
When melatonin was administered to experimental mice, the beta-amyloid remaining in the mice’s brains was reduced by more than 200%, and when melatonin was administered to patients with mild cognitive impairment, the rating scale improved by 25% . [사진=코메디닷컴 DB]One way to supplement melatonin is to eat healthy foods. Korea bans the import of melatonin-based health foods from abroad, but allows the sale of domestically produced plant-based melatonin products. Plant melatonin products are derived from plant ingredients and have a low risk of side effects during the synthesis process. Furthermore, since it is a substance originally present in the body, it does not cause addiction, withdrawal symptoms or tolerance.
Research related to melatonin is also steadily progressing. When Professor Miguel Pappola’s research group at the University of Texas at Galveston administered high-concentration melatonin to experimental mice, the amount of beta-amyloid released into the lymphatic vessels increased by 300% and the amount of beta-amyloid that remained in the brain it decreased by 30%. more than 200%. Buenos Aires Medical School in Argentina had patients with mild cognitive impairment take 3 to 9 mg of oral melatonin daily, and it was found that users’ Alzheimer’s dementia rating scale improved by 25 percent. Depressive symptoms and sleep quality also improved significantly.
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