Fna C2, a subtype of Fusobacterium nucleatum, is an accomplice.
Posted on 03.22.2024 at 7.00pm Posted on 03.22.2024 at 7.00pm Modified on 03.22.2024 at 4.43pm Views 18
It has been consistently confirmed that patients with colon tumors containing Fusobacterium nucleatum have a lower survival rate and worse prognosis than patients without the microorganisms. [사진= 게티이미지뱅크]A new study has found that bacteria that commonly live in the human mouth can migrate to colon tumors and appear to accelerate their growth. This is what the health and medicine webzine “Health Day” reported on the 21st (local time), based on a statement by researchers from the Fred Hutchinson Cancer Center in the United States published in Nature.
The researchers examined levels of Fusobacterium nucleatum, a member of the oral bacteria, in colon tumor tissue collected from 200 colon cancer patients. There are several subtypes of this bacterium, but only one subtype, called Fna C2, has been found in colon tumors. The Fna C2 subtype was also found more frequently in stool samples collected from colon cancer patients compared to healthy individuals.
“We found that patients with colon tumors containing Fusobacterium nucleatum had lower survival rates and a worse prognosis than patients without microbes,” said Susan Bulman, a molecular microbiologist at the Fred Hutchinson Cancer Center and one of the leaders of the study. ” He said. “We found that a specific subtype of this microbiome is responsible for tumor growth. This means that testing and treatments targeting this subtype may help people at high risk for this more aggressive colorectal cancer.” ,” he said.
The researchers found that only the Fna C2 subtype had the ability to travel from the mouth to the stomach and then spread to the lower gastrointestinal tract, including the colon. The Fna C2 subtype was found in 50% of colon cancers examined by researchers.
According to researchers, microbe-based “cell therapy” could represent a new frontier in the attack on colon cancer. These treatments use modified forms of bacteria to deliver drugs directly to tumors, they explained.
“We have accurately identified bacterial strains associated with colon cancer,” said Christopher Johnston, molecular microbiologist and co-principal investigator. “This knowledge is very important for developing effective prevention and treatment methods.” According to the American Cancer Society (ACS), 52,000 people die from colon cancer each year in the United States.
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