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Waldenström’s Macroglobulinemia: Understanding the Rare Blood Cancer
Table of Contents
Waldenström’s macroglobulinemia, a rare form of blood cancer, accounts for 1% to 2% of hematological cancers. According to 2018 data, there were an estimated 1,317 new cases in France, with a higher incidence in men (68%) compared to women (32%). “There is a slight male predominance, as seen in many hematological cancers, though the exact reason remains unclear,” said a hematologist.
What is Waldenström’s Macroglobulinemia?
Waldenström’s macroglobulinemia, named after the Swedish doctor who first described it in 1944, is a cancer affecting white blood cells, specifically B lymphocytes. It is classified as an indolent lymphoma, characterized by its slow progression.
The average age at diagnosis is around 70 years,making it primarily a disease affecting older adults.
What Causes Waldenström’s Macroglobulinemia? Is it Hereditary?
The precise cause of Waldenström’s macroglobulinemia remains unknown. Though, research indicates that nearly all cases involve a mutation in the MyD88 gene.
The hematologist notes, ”In addition to this acquired mutation, a familial genetic component is highly likely.” Studies suggest that 20% to 30% of patients have a family history of Waldenström’s macroglobulinemia, IgM monoclonal gammopathy, or lymphoma.
what are the Symptoms?
Many individuals with Waldenström’s macroglobulinemia are asymptomatic, with the condition discovered incidentally during routine blood tests.The hematologist explains, “We observe a ‘peak’ of antibodies – specifically immunoglobulin M (IgM) monoclonal – produced in excess by abnormal lymphocytes.” In such cases, immediate treatment isn’t necessary, but regular monitoring, typically every six months, is recommended.
When symptomatic, Waldenström’s macroglobulinemia can manifest in several ways:
- Swollen lymph nodes
- Enlarged spleen
- Anemia (leading to fatigue and shortness of breath)
Excessive IgM production can also trigger neurological and renal symptoms, complicating diagnosis. The specialist adds that overproduced immunoglobulin (IgM) can lead to:
- peripheral neuropathy: Tingling, numbness, decreased sensitivity, balance issues, and pain in the extremities.
- Hyperviscosity syndrome: Increased blood viscosity, reducing blood flow to the skin, fingers, nose, and brain, perhaps causing chronic nosebleeds, headaches, dizziness, tinnitus, and retinal hemorrhages that can impair vision.
- cold agglutinin disease: High concentrations of antibodies targeting red blood cells, leading to hemolytic anemia (red blood cell destruction).
- Kidney damage: In rare cases, potentially progressing to renal failure.
How is Waldenström’s Macroglobulinemia Diagnosed?
Diagnosis typically begins with a blood test called protein electrophoresis. “The presence of a large quantity of IgM antibodies produced by abnormal lymphocytes results in a ‘peak’,” the hematologist explains. “This peak is present in all cases of Waldenström’s macroglobulinemia and is an essential diagnostic criterion. Without the peak, it is not Waldenström’s disease.”
A positive serum protein electrophoresis result necessitates a bone marrow examination.This procedure, performed under local anesthesia, involves extracting a small amount of marrow from a bone (sternum or hip) using a hollow needle for analysis.
What are the Treatment Options?
Management of Waldenström’s macroglobulinemia depends on whether the patient is symptomatic. Asymptomatic patients typically do not require treatment.
According to hematology experts, ”Treating a person without symptoms exposes them to the potential side effects of drugs.Therapeutic abstention is currently the best option in these cases.”
For symptomatic patients, treatment primarily involves a combination of immunotherapy and chemotherapy (immunochemotherapy). The hematologist states, “Immunochemotherapies are generally well-tolerated today and can control the disease long-term. Targeted therapies are also utilized.”
Living with Waldenström’s Macroglobulinemia
While current treatments may not cure the disease, they are highly effective in preventing its progression. “Symptoms disappear, monoclonal IgM levels considerably decrease, and the disease stabilizes,” reports hematology experts.Remission duration varies among patients, typically lasting several years.
Life Expectancy
Today,the life expectancy of patients with Waldenström’s macroglobulinemia is comparable to that of the general population of the same age.
Waldenström’s Macroglobulinemia: Understanding the Rare Blood Cancer
Welcome to this comprehensive guide on Waldenström’s macroglobulinemia (WM). We’ll explore this rare blood cancer in detail,answering common questions and providing valuable insights.
What is Waldenström’s Macroglobulinemia?
Waldenström’s macroglobulinemia is a rare type of blood cancer, accounting for approximately 1% to 2% of all hematological cancers. It is indeed classified as an indolent lymphoma, meaning that it progresses slowly. It was first described in 1944 by the Swedish doctor, Jan waldenström, after whom the disease is named.
Who is Affected by WM?
The average age at diagnosis is around 70 years, indicating that it primarily affects older adults. there is also a slight male predominance. 2018 data showed that in France, there were an estimated 1,317 new cases of WM. Studies show that 68% of cases occurred in men and 32% in women.
What Causes waldenström’s Macroglobulinemia? Is it Hereditary?
The exact cause of Waldenström’s macroglobulinemia is unknown. However, research indicates that almost all cases involve a mutation in the MyD88 gene.
A hematologist notes that a familial genetic component is also highly likely. Studies suggest that between 20% to 30% of patients have a family history of WM, IgM monoclonal gammopathy, or lymphoma.
What are the Symptoms of Waldenström’s Macroglobulinemia?
Many individuals with WM are asymptomatic, meaning
