Study Confirms Link Between Inflammatory Bowel Disease and Risk of Vertebral Fractures

[김태열의 생생건강S펜] “Confirmation of the causal relationship between risk of vertebral fracture in patients with inflammatory bowel disease”

As a result of the research team’s analysis of various variables such as age and gender of the study subjects, comorbidities, whether surgery was performed after the diagnosis of spinal fracture and the status of drug treatment, it was found that the risk of vertebral fractures in patients with inflammatory bowel disease was higher than that in the general public. 〈Photo Source: Getty Image Bank〉

[헤럴드경제=김태열 건강의학 선임기자] Research has shown that inflammatory bowel disease, which causes inflammation in the intestines from an unknown cause, causing abdominal pain and blood in the stool, increases the risk of spinal fractures. Long-term use of steroids for treatment, along with the chronicity of inflammatory bowel disease and the aging patient population, have been identified as major factors influencing spinal fractures.

The research team, led by Professor Jeong Seong-hoon of the Department of Gastroenterology (first author) and Professor Jun-seok Lee of the Department of Orthopedics (corresponding author) of Eunpyeong St. Mary’s Hospital, Catholic University of Korea, used data from the National Health Insurance Corporation from 2008 to 2018 studying 33,778 patients with inflammatory bowel disease and 10 members of the general public. A large-scale comparative study of risk factors for the onset and severity of spinal fractures was conducted in 1,265 people.

As a result of the research team’s analysis of various variables such as age and gender of the study subjects, comorbidities, whether surgery was performed after the diagnosis of spinal fracture and the status of drug treatment, it was found that the risk of vertebral fractures in patients with inflammatory bowel disease was higher than that in the general public. Notably, among patients with inflammatory bowel disease, vertebral fractures occurred more frequently and more severely in patients with Crohn’s disease. When the risk of vertebral fractures in the general population was set to 1, there was a significant difference of 1.59 for patients with Crohn’s disease and 1.27. for patients with ulcerative colitis. The risk of exposure to severe or more severe spinal fractures was also elevated, at 1.82 for patients with Crohn’s disease and 1.49 for patients with inflammatory bowel disease.

Factors influencing vertebral fractures were Crohn’s disease, advanced age, female sex, high comorbidity index, and long-term steroid use. In the case of steroids, a significant difference in the incidence of vertebral fractures was found depending on the duration of use. Inflammatory bowel disease is a disease in which chronic, recurrent inflammation occurs in the gastrointestinal tract, and Crohn’s disease and ulcerative colitis are representative examples. Chronic intestinal inflammation causes abdominal pain, diarrhea, blood in the stool, and malabsorption of iron, zinc, calcium, and vitamin D, which have serious adverse health effects. Additionally, steroids and immunomodulators used to treat inflammatory bowel disease may have a negative effect on bone metabolism. However, until now, it was not known whether the risk and severity of spinal fractures actually differed between patients with inflammatory bowel disease and the general population, or how the patterns differed between patients with Crohn’s disease and ulcerative colitis.

Professor Lee Jun-seok from the Department of Orthopedics at Eunpyeong St. Mary’s Hospital said: “Spine fractures, which add to the socioeconomic burden of patients, may be caused by osteoporosis due to aging and menopause, but they can also be caused by secondary diseases. osteoporosis caused by chronic diseases or drug treatments.” “This study is of great importance as it identifies the current state of spinal fractures that occur due to chronic intestinal diseases or long-term use of specific drugs,” he explained .

Professor Jeong Seong-hoon from the Department of Gastroenterology said: “Through this study, we specifically confirmed the correlation and risk factors between inflammatory bowel disease and spinal fractures. We looked closely at gender, age and the complexity of the patient”. concomitant diseases and, moreover, regularly “Active efforts are needed to monitor human bone density, provide vitamin D and reduce the use of steroid treatments,” he said.

kty@heraldcorp.com

COPYRIGHT ⓒ HERALD CORPORATION. All rights reserved.

#김태열의 #생생건강S펜 #Confirmation #causal #relationship #risk #vertebral #fracture #patients #inflammatory #bowel #disease