The “OXR1 gene” has a significant impact on the prevention of dementia and Parkinson’s disease by slowing down the aging process of brain cells
Posted on 16.01.2024 16:10 Views 473 Posted on 16.01.2024 16:10 Modified 16.01.2024 15:38 Views 473
Eating less food through intermittent fasting and calorie restriction can help improve brain health and extend your lifespan. This is where a specific diet gene (OXR1 gene) comes into play. [사진=게티이미지뱅크]It has been shown that reducing food intake can slow brain aging and increase lifespan. This is due to a specific “diet gene”.
The Buck Institute on Aging in the United States announced that research in fruit flies and human cells has shown that a low-calorie diet slows brain aging and helps extend lifespan, and that a specific food gene (gene OXR1) plays an important role in this.
The results of this study (OXR1 maintains retromer to delay brain aging in case of dietary restrictions) were published in the international journal Nature Communications and presented by Studyfinds, an American science and culture portal.
“It’s common to think that limiting food intake can affect the digestive tract or fat storage, but eating less also activates certain dietary genes,” said Dr. Kenneth Wilson, a postdoctoral researcher and first author of the study. “It plays an important role in brain health and longevity.” He said: “Diet can slow the progression of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. “This process is promoted mainly by specific dietary genes that play a key role in protecting brain cells from aging and neurological disorders,” he added. It is expected that the results of this study will be used to develop new anti-aging drugs.
The research team discovered specific neuronal responses that mediate the neuroprotection of food restriction. Intermittent fasting or calorie restriction that limits nutrients can increase levels of certain dietary genes. “Some diet genes are important factors of brain resilience and play an important role in preventing aging and neurological diseases,” said Dr. Pankaj Kapahi, lead author of the study.
The research team studied and analyzed changes in approximately 200 strains of fruit flies based on various diets. The results showed that certain genetic mutations, including a specific food gene (OXR1 gene) known as “mustard” or “mtd” in fruit flies, had a significant impact on lifespan on a low-calorie diet. Furthermore, this gene has been found to protect cells from oxidative damage. Cellular damage can lead to serious neurological defects and premature death.
In particular, this gene was found to influence a specific protein complex (retromer) essential for the recycling of cellular proteins and lipids. “Retromers determine the fate of every protein that enters the cell,” Dr. Wilson said. “This is a very important mechanism in neurons.” “Diet has a big impact on these genes,” he said. “Eating less food strengthens the mechanism by which cells correctly select proteins and cells strengthen the expression of OXR1,” he explained. The research team plans to work on finding compounds that can delay brain aging and extend lifespan by increasing OXR1 levels in humans.
Journalist Kim Young-seop
edwdkim@kormedi.com
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