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Understanding SLE and Autoimmune Disease: Different Inflammation in Each Organ with Varying Symptoms

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Patients with Systemic Lupus Erythematosus (SLE) or autoimmune disease can experience inflammation in different organs, leading to various symptoms. However, multiple organ inflammation is quite common.

Rajavithi Hospital has revealed that SLE is a disease that causes inflammation and damage to organs throughout the body. Each patient may have different organ inflammation and symptoms, but it frequently involves multiple organs. It is advised that patients closely monitor their symptoms and seek immediate medical attention if any abnormalities are found.

Dr. Nattapong Wongwiwat, Deputy Director General of the Department of Medical Services, explained that SLE stands for Systemic Lupus Erythematosus, which is a rare autoimmune disease. It has a low mortality rate, affecting only 0.1% of the population in Thailand (approximately 50,000 – 700,000 people). It is most commonly found in women aged between 20 and 40 years old. The exact cause of the disease is still unknown, but it may be related to genetics, sunlight, viral and bacterial infections, vaccinations, certain drugs, or chemicals.

Chinda Rojamethin, Director of Rajavithi Hospital, discussed the typical symptoms of SLE. Patients often experience low fever, joint pain, fatigue, loss of appetite, weight loss, hair loss, rash on the face resembling butterfly wings, rash on the limbs, rash photosensitivity, mouth ulcers, swelling, paleness, bruising, or red spots on the limbs. These symptoms usually precede a formal diagnosis by weeks or sometimes months. Doctors diagnose the condition through blood tests, urinalysis, and immunological tests using diagnostic criteria from the American and European Society of Rheumatology.

Dr. Soongchai Angthararak, specialist physician and Head of Rheumatology and Allergy Internal Medicine at Rajavithi Hospital, emphasized the importance of strict adherence to prescribed medications for SLE. The treatment usually includes antimalarial drugs in combination with other immunosuppressants and steroid drugs, with the dosage and administration method based on the severity of the disease. Patients should practice cleanliness, consume clean food, avoid infections, promptly take prescribed medications, avoid herbal or over-the-counter medicines, and consult their doctor regarding sunlight exposure, stress management, and contraception if applicable.

If SLE patients experience abdominal pain, it may be caused by various factors like peptic ulcer disease, stomach ulcers, enteritis, or appendicitis. However, SLE itself can cause abdominal organ inflammation or gastrointestinal tract inflammation. Timely diagnosis and treatment are crucial, including peritonitis, gastrointestinal artery inflammation, enteritis, and pancreatitis. Patients may experience symptoms such as abdominal pain, bloating, nausea, vomiting, and diarrhea. Delayed treatment can lead to severe complications like intestinal decay or arteritis. Computed tomography (CT scan) is used for diagnosis, and treatment may involve intravenous fluids, high-dose steroid administration, fibrinolytic drugs, or surgical repair.

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Patients with ‘SLE’ or ‘autoimmune’ can have different inflammation in each organ. and they have different symptoms But often inflammation of many organs together.

Rajavithi Hospital The Department of Medicine reveals SLE It is a disease that causes inflammation of organs throughout the body. and organs that are inflamed will be damaged Each patient can have different inflammation in each organ and symptoms. show differently But often inflammation of many organs together. Advise patients to keep an eye on their symptoms. If abnormalities are found, you should see a doctor immediately.

Dr said. Nattapong Wongwiwat, Deputy Director General of the Department of Medical Services SLE It stands for Systemic Lupus Erythematosus. is an autoimmune disease or diseaseautoimmune It is a rare disease. and has a low mortality rate. found only 0.1% (0.014 – 0.122) or the number of patients in Thailand is about 50,000 – 700,000 people, most often found in women between 20 – 40 years old. At the moment, the exact cause of the disease is still unknown. But it may be related to genetics, sunlight, viral infections. Bacterial infections, vaccinations, certain drugs or chemicals

Chinda Rojamethin, DirectorRajavithi Hospital Discuss the most common symptoms of SLE or diseaseautoimmuneThat is, the patient usually has a low fever, joint pain, aches, fatigue, fatigue, loss of appetite, weight loss, hair loss, rash on the face, cheeks like butterfly wings, rash on the limbs, rash photosensitivity, mouth ulcers, swelling, paleness, bruising or red spots like mosquito bites on the limbs. Symptoms usually precede by weeks or weeks. for diagnosis The doctor will diagnose the patient with a blood test to look for inflammation of the organs. urinalysis and immunological tests (ANA, anti-dsDNA, anti Sm) using diagnostic criteria from the American and European Society of Rheumatology.

Dr Soongchai Angthararak, specialist physician Head of Rheumatology and Allergy Internal Medicine Rajavithi Hospital He added that the patient SLE or diseaseautoimmune Medicines must be taken strictly as prescribed by a doctor, using medicines including antimalarial drugs. in combination with other immunosuppressant steroid drugs The amount and method of drug administration will depend on the severity of the disease, including that the patient must take care of himself, including cleanliness. eat clean food Beware of infection take the medicine straight away and don’t stop taking the drug yourself Avoid herbal or over the counter medicines. Informal supplements avoid sunlight reduce or avoid stress contraception If you are pregnant, you should consult your doctor.

for patients SLE with abdominal pain May be caused by peptic ulcer disease. Stomach ulcers, enteritis, appendicitis Like other people, however, SLE itself can be inflammation of the abdominal organs or in the gastrointestinal tract from SLE itself. but with urgency

Diagnosis and treatment include peritonitis. arteries in the gastrointestinal tract and enteritis pancreatitis Where the patient will bring pain in the abdomen, flatulence, nausea, vomiting, may have diarrhea. Abdominal pain is often quite severe and usually lasts for days or days. Abdominal examination reveals flatulence. Pressing pain across the abdomen reduced bowel function Diagnosis is based on a blood test that assesses inflammation. Evaluate liver and kidney function values ​​Assess blood minerals and to check for amylase or lipase enzymes to assess pancreatic insufficiency Computed tomography (CT scan) of the abdomen will help with the diagnosis. pancreatitis, where the pancreas is swollen and intestinal vasculitis, characterized by a thick, swollen, donut-like bowel

Treatment involves giving intravenous fluids. and high dose steroid administration for inflammatory bowel disease If treatment is delayed, it can lead to intestinal rot and death. As well as arteritis the intestines were found to be rotten. It can be caused by arteriosclerosis from blood clots. Because the immune system encourages blood to clot more easily than usual. which is a less common condition Patients usually do not have inflammation in other systems. Diagnosis using computed tomography. Along with the injection of color will be finding the clogging point. Treatment includes the use of fibrinolytic drugs, and other less common symptoms include inflammation of the aorta and a tear in the aortic wall. The patient will have quite severe abdominal pain. And if the arterial wall is broken, it usually dies quite quickly. Diagnosis is difficult and treatment requires urgent surgical repair along with high dose steroid therapy.

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