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One study showed that when mice with dementia were fed a so-called “low-carb, high-fat” ketogenic diet (hereinafter referred to as “keto”), early memory decline was significantly delayed.
According to Neuroscience News on the 19th (local time), the team of Professor Gino Cortopasi from the School of Veterinary Medicine at the University of California, Davis, USA, published a study on the same day in the academic journal “Communications Biology” of the Nature Group, where a mouse model of Alzheimer’s disease was fed a keto diet and a regular diet for 7 months, it turned out that these results were confirmed through a comparative experiment with liver feeding.
The keto diet is a diet that consumes low carbohydrates, high fat, and an adequate amount of protein and is called “low-carb, high-fat” in Korea.
The keto diet is known to change your metabolism by burning fat instead of glucose, the body’s main fuel, and producing ketones (an acid produced in the process of using fat as an energy source) for energy.
Through previous research, the research team found that the lifespan of mice eating a keto diet was about 13% longer than that of mice eating a normal diet.
Subsequently, through further animal studies, it was confirmed that “beta-hydroxybutyrate” (hereinafter “BHB”), which is secreted in large quantities when consuming a keto diet, plays an important role in preventing memory decline in early stages of Alzheimer’s.
The experiment was conducted for a total of 7 months, comparing dementia rats eating a keto diet with dementia rats eating a regular diet. As a result, it was confirmed that the function of the “synapse,” a small structure that connects all the nerve cells in the brain, was improved in mice following the keto diet.
In the brain hippocampus of mice on a keto diet, the level of beta-amyloid (Aβ), known to cause dementia, did not change, but beta-hydroxybutyrate (BHB), an indicator of ketones in the blood, increased by almost seven times. fold.
“We confirmed the remarkable ability of BHB to improve synaptic function in the brain,” said co-corresponding author Professor Izumi Maezawa of the UC Davis Department of Pathology, “When brain neurons become better connected, the mild cognitive deterioration and memory problems are resolved.” He explained.
“This suggests that BHB plays a critical role in preventing early memory decline,” Professor Kortopasi said. “These findings raise the idea that the keto diet, and BHB in particular, may slow mild cognitive impairment and delay the progression of Alzheimer’s disease.” I support it,” he said.
He went on to say that the mouse model corresponds to mild cognitive impairment of Alzheimer’s disease in humans, and that because the keto diet and BHB are approved diets and dietary supplements, respectively, it presents a new possibility to therapeutically link Alzheimer’s disease at the MCI stadium.
The team also found that the keto diet increases biochemical pathways involved in memory formation in rats and appears to be more effective in females than males.
Reporter Seo Hee-won shw@etnews.com
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