Australian Research Team Discovers Promising Treatment for Sepsis
Seoul, 26th October 2023 – In groundbreaking research, an Australian team has found that sodium ascorbate, a balanced form of vitamin C, shows potential in treating sepsis, a life-threatening condition caused by blood infection. Sepsis triggers a systemic inflammatory response that can lead to organ failure and death, accounting for a significant percentage of hospital fatalities.
The study, led by Professor Yugesh Rankadeva’s team at the Florey Research Institute Emergency Medicine Laboratory at the University of Melbourne, conducted an initial clinical trial with 30 adult sepsis patients between October 2020 and November 2022. Half of the patients were randomly assigned sodium ascorbate, while the other half received a placebo.
Remarkably, the group administered with sodium ascorbate displayed improvements in various organ functions. Notably, kidney function improved as urine output increased, and the dosage of noradrenaline, a blood pressure-restoring drug, was reduced. Pre-clinical tests conducted prior to the trial even showed that sepsis completely disappeared within three hours of administering the highest dose of sodium ascorbate, without any side effects.
These promising findings pave the way for further clinical trials, set to commence in November, involving 300 sepsis patients across medical institutions in Australia. The research team plans to explore the potential of sodium ascorbate for larger-scale use.
The results of this groundbreaking study have been published in the latest issue of the esteemed scientific journal Biomed Central-Critical Care (BMC). This research breakthrough offers hope for effectively combating sepsis, a condition that poses a significant challenge to healthcare professionals worldwide.
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skhan@yna.co.kr
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Australian research team “Sodium ascorbate, effect of sepsis”
2023.10.26 08:07 Write a comment
(Seoul = Yonhap News) Reporter Han Seong-gan = Research results have shown that sodium ascorbate is effective in treating sepsis, a fatal disease caused by blood infection by bacteria. Sodium ascorbate is a balanced vitamin C so that the hydrogen ion concentration index (pH) is balanced.
Sepsis is a systemic inflammatory reaction where inflammation erupts due to an overreaction of the immune system when the blood becomes infected with bacteria that invade the human body, and is a fatal disease that leads to organ failure multiple and death. Sepsis accounts for 35-50% of all hospital deaths.
The American Association for the Advancement of Science said that Professor Yugesh Rankadeva’s research team at the Florey Research Institute Emergency Medicine Laboratory at the University of Melbourne, Australia, found these results in an initial clinical trial conducted on 30 adult sepsis patients between October 2020 and November. 2022. Science news site (AAAS) EurekAlert reported on the 24th.
In the clinical trial, half of the 30 people were randomly given sodium ascorbate and the other half were given a placebo.
As a result, the group administered sodium ascorbate showed signs of improvement in various organ functions.
The research team said that as the amount of urine increased, there were signs of improvement in kidney function, and the dose of noradrenaline, a drug used clinically to restore blood pressure, was reduced.
In pre-clinical tests carried out before clinical trials, when sodium ascorbate was given at the highest dose, sepsis completely disappeared without side effects in just 3 hours.
The research team plans to conduct the next phase of clinical trials on 300 sepsis patients at medical institutions across Australia starting in November.
The results of this study were published in the latest issue of the online scientific journal Biomed Central-Critical Care (BMC).
skhan@yna.co.kr
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