ㅣGerman Center for Cancer Research and Research Group of the University of Tübingen, mouse experiment
ㅣ5:2 Intermittent fasting is effective in reducing weight and preventing hepatitis and liver cancer.
ㅣIt is effective in the treatment of steatohepatitis related to metabolic abnormalities
Research findings have shown that 5:2 intermittent fasting, which involves not starving yourself for two days a week, is effective not only in preventing but also treating diseases such as hepatitis and liver cancer. The results of this study (a 5:2 intermittent fasting regimen improves NASH and fibrosis and attenuates the development of HCC via PPARα and hepatic PCK1, 5:2 intermittent fasting improves non-alcoholic fatty liver disease and hepatic fibrosis via PPARα and PCK1 in the liver and prevents the development of hepatocellular carcinoma) suppresses) was recently published in the international academic journal ‘Cell Metabolism’.
Research results have shown that 5:2 intermittent fasting, which involves not eating two days a week, is effective in preventing and treating liver diseaseㅣSource: Midjourney
A research team from the German Center for Cancer Research and the University of Tübingen has confirmed the effect of intermittent fasting on liver health in mice.
The research team fed the mice a diet high in sugar and fat, a typical Western diet. However, the experimental rats were divided into two groups, one group that continuously ate high-fat food and the other group underwent 5:2 intermittent fasting, in which they were fed nothing for two days and were allowed to eat the maximum amount of food possible. as they wanted for five days.
As a result of the study, it was revealed that mice in the group continuously fed foods high in sugar and fat increased body weight and body fat and developed metabolic abnormality-related steatohepatitis (MASH). On the other hand, mice in the 5:2 intermittent fasting group did not gain weight even though they ate high-fat foods and levels of liver damage were low. What is notable is that the total amount of calories consumed by the two groups of mice was similar.
The research team found that 5:2 intermittent fasting, which involves fasting for two days a week, is more effective than other forms of intermittent fasting, such as fasting for one day.
To confirm the exact mechanism, the researchers compared the protein composition and genetic activity in the livers of experimental mice. As a result, intermittent fasting has been found to increase gluconeogenesis, which influences fatty acid degradation and blood sugar control, and activates enzymes such as PPARα and PCK1, which suppress fat accumulation.
The research team conducted an additional experiment in which mice that had already developed MASH on a Western-style diet were subjected to 5:2 intermittent fasting for 4 months. As a result, it was found that the fatty liver levels of mice practicing intermittent fasting were improved and the incidence of liver cancer was reduced.
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