Posted on 03.12.2024 at 10.47am Posted on 03.12.2024 at 10.47am Views 1,376
Melatonin has the function of eliminating free radicals. [사진=클립아트코리아]’Anti age’
When we hear this, we often think of a wrinkle-free face. However, anti-aging in the medical sense does not simply mean preventing sagging skin. Anti-aging includes everything from escaping the risk of adult diseases that occur with advancing age to returning to a state similar to the biological reactions and structures of younger people.
In this context there is a substance that the US Food and Drug Administration (FDA) has officially recognized as having an anti-aging effect. It’s melatonin. Melatonin is a hormone produced by the pineal gland in the brain and by the mitochondria of all cells in the body. When the sun sets, signals are transmitted to the brain through the retina and secreted by the pineal gland. Melatonin, which then spreads throughout the body through the blood, controls more than 500 genes to restore and regenerate most organs, including the heart, blood vessels, liver and skin. In particular, it has an excellent ability to ward off free radicals, the main cause of aging. This is why melatonin is called the “aging neutralizer” or “rejuvenation hormone”.
Active oxygen is a waste product generated during the metabolic process of the human body. Unpaired unstable oxygen radicals have a strong tendency to combine with other things in the body to form a stable structure. In this process it attacks the cell membrane, destroying the cell structure and damaging the DNA inside the cell nucleus. Mutant cells can be created that cause various diseases such as aging, cancer, cardiovascular disease and brain disease.
The medical community believes that free radicals cause approximately 90% of the 36,000 diseases humanity suffers from. Therefore, anti-aging research also focuses on how to reduce free radicals.
The special antioxidant capacity of melatonin
Commonly known antioxidants such as coenzyme Q10, vitamin C, vitamin E, and glutathione neutralize free radicals by giving them an electron and remove free radicals by oxidizing. It reacts one by one and then disappears.
On the other hand, melatonin does not lose its antioxidant capacity even after the removal of free radicals. Furthermore, the metabolites produced in this process also have strong antioxidant power and even increase the activity of enzymes. This triple antioxidant system is an ability that comes from the way melatonin works, which removes free radicals through molecular rearrangement rather than through oxidation/reduction reactions like other antioxidants.
Furthermore, according to several research results, one molecule of melatonin can remove up to 10 oxides through secondary and tertiary processes and has a powerful antioxidant capacity that is 10 times that of vitamin E and 13 times that of vitamin C. Its ability to prevent DNA damage is 60 to 70 times stronger than vitamins C and E.
According to a study that compared several antioxidants, including melatonin, its metabolites and vitamin C, the antioxidant power of melatonin was superior to that of glutathione, resveratrol and vitamin C. [그래프=코메디닷컴 DB] Additionally, the effects of melatonin can be seen through the relationship between melatonin and telomeres. Telomeres, studied by Dr. Jack Stack, winner of the 2009 Nobel Prize in Physiology or Medicine, are known to be genetic material that determines aging and lifespan. The substance that can extend lifespan by maintaining telomere length is a component called sirtuin, and it has been confirmed that melatonin is the main factor that activates this sirtuin.
Various animal experiments have also revealed the lifespan-prolonging effect of melatonin. The Emmanuel Institute of Biochemistry and Physics in Moscow, Russia, reported that when animals were given melatonin daily, their lifespan increased by 25%. The Emmanuel Institute of Biochemistry and Physics of Venezuela also announced that the maximum life span of the group administered melatonin increased by 33.2%.
Due to these characteristics, the US FDA has officially recognized melatonin as a substance with anti-aging effects. In an article jointly published by medical experts from the United States, Germany and Bulgaria, melatonin is called an “aging neutralizer.” As a result, the size of the melatonin market is growing rapidly in the United States.
Approved for sale of “vegetable melatonin” in Korea
Until now, melatonin was classified as a prescription drug in Korea and could only be purchased with a doctor’s prescription. However, since plant melatonin extracted from plants has recently been developed and approved as a health food, plant melatonin supplements in the form of generic foods have become available online in Korea.
Unlike synthetic melatonin, which is classified as a prescription drug, plant-based melatonin is made from plant extracts. It can be a safe option due to the low risk of resistance or side effects. However, among the commercially available products, there are products that advertise as containing melatonin by adding small amounts of ingredients such as GABA, black cherry and tryptophan, which are involved in the production of melatonin in the body. Therefore, when purchasing a product, you should check the raw materials and contents to see if it contains real melatonin of plant origin.
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